2-Octyl-2H-isothiazol-3-one
Names
[ CAS No. ]:
26530-20-1
[ Name ]:
2-Octyl-2H-isothiazol-3-one
[Synonym ]:
3(2H)-Isothiazolone,2-octyl
2-Octyl-4-isothiazolin-3-one
octhilinone [ANSI]
2-n-octyl-3-isothiazolone
3(2H)-Isothiazolone, 2-octyl-
Pancil
T5SNVJ B8
Micro-chek skane
2-n-Octyl-4-isothiazolin-3-one
Kathon SP 70
2-Octyl-3(2H)-isothiazolone,Octhilinone
2-Octyl-3-isothiazolone
2-octyl-2H-isothiazol-3-one
2-octyl-1,2-thiazol-3-one
MFCD00072473
2-octylisothiazol-3(2H)-one
EINECS 247-761-7
2-Octyl-1,2-thiazol-3(2H)-one
Octhilinone
2-octylisothiazolin-3-one
Skane 8
2-Octyl-3(2H)-isothiazolone
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
304.5±25.0 °C at 760 mmHg
[ Melting Point ]:
23 °C
[ Molecular Formula ]:
C11H19NOS
[ Molecular Weight ]:
213.340
[ Flash Point ]:
137.9±23.2 °C
[ Exact Mass ]:
213.118729
[ PSA ]:
50.24000
[ LogP ]:
3.77
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.519
[ Storage condition ]:
Refrigerator
[ Stability ]:
Stable. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
<0.1 g/100 mL at 19 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NX8156900
- CHEMICAL NAME :
- 4-Isothiazolin-3-one, 2-octyl-
- CAS REGISTRY NUMBER :
- 26530-20-1
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C11-H19-N-O-S
- MOLECULAR WEIGHT :
- 213.37
- WISWESSER LINE NOTATION :
- T5SNVJ B8
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- MosJN# Personal Communication from J.N. Moss, Toxicology Dept., Rohm and Haas Co., Spring House, PA 19477, Aug. 15, 1979 Volume(issue)/page/year: 15AUG1979
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- MosJN# Personal Communication from J.N. Moss, Toxicology Dept., Rohm and Haas Co., Spring House, PA 19477, Aug. 15, 1979 Volume(issue)/page/year: 15AUG1979 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 550 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MosJN# Personal Communication from J.N. Moss, Toxicology Dept., Rohm and Haas Co., Spring House, PA 19477, Aug. 15, 1979 Volume(issue)/page/year: 15AUG1979
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JALCAQ Journal of the American Leather Chemists' Association. (American Leather Chemists' Association, Tanners' Council Research Laboratory, Room 10, Campus Station, Cincinnati, OH 45221) V.1- 1906- Volume(issue)/page/year: 74,322,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 690 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MosJN# Personal Communication from J.N. Moss, Toxicology Dept., Rohm and Haas Co., Spring House, PA 19477, Aug. 15, 1979 Volume(issue)/page/year: 15AUG1979 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1443 No. of Facilities: 237 (estimated) No. of Industries: 4 No. of Occupations: 7 No. of Employees: 2782 (estimated) No. of Female Employees: 23 (estimated)
Safety Information
[ Symbol ]:
GHS05, GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H311 + H331-H314-H317-H410
[ Precautionary Statements ]:
P261-P273-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic
[ Risk Phrases ]:
R22;R23/24;R34;R43;R50/53
[ Safety Phrases ]:
S1/2-S26-S36/37/39-S45-S60-S61
[ RIDADR ]:
2922
[ RTECS ]:
NX8156900
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
3808940090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934100017
[ Summary ]:
2934100017 2-octylisothiazol-3(2h)-one。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%
Articles
Contact Dermatitis 50(1) , 47-8, (2004)
Allergic contact dermatitis from 2-n-octyl-4-isothiazolin-3-one, a paint mildewcide.
Contact Dermatitis 9(6) , 507-9, (1983)
Severe allergic contact dermatitis from a paint mildewcide, 2-n-octyl-4-isothiazolin-3-one, developed in a worker formulating latex paints within a paint manufacturing company, Guinea pig maximization...
[Allergic contact eczema caused by isothiazolin-3-one derivatives].Derm. Beruf Umwelt. 32(6) , 208-11, (1984)
Observations concerning contact dermatitis to derivatives of isothiazolin-3-one are reported. A systematic review of the literature of previously published cases is reported. A verified contact dermat...