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Poly-D-lysine hydrobromide (MW 30000-70000)

Names

[ CAS No. ]:
27964-99-4

[ Name ]:
Poly-D-lysine hydrobromide (MW 30000-70000)

[Synonym ]:
MFCD00131934
Lysine hydrobromide (1:1)
Lysine, hydrobromide (1:1)

Biological Activity

[Description]:

Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide (MW 30000-70000) removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrPC[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Poly-D-lysine is immunogenic in rabbits only when injected at low doses[1]. The approximate concentration of Poly-D-lysine (PDL) needed to lower the amount of PrPres by 50% corresponds to ~0.8 μg/mL or 50 nM[2].

[References]

[1]. HansVermeersch, et al. Immunogenicity of poly-D-lysine, a potential polymeric drug carrier. Journal of Controlled Release. Volume 32, Issue 3, 1 December 1994, Pages 225-229.

[2]. Zhou Xu, et al. Mechanistic insights into cellular alteration of prion by poly-D-lysine: the role of H2H3 domain. FASEB J. 2011 Oct;25(10):3426-35.

Chemical & Physical Properties

[ Boiling Point ]:
343.7±0.0 °C at 760 mmHg

[ Molecular Formula ]:
(C6H14N2O2)x.xBrH

[ Molecular Weight ]:
30000-70000

[ Flash Point ]:
161.7±0.0 °C

[ Exact Mass ]:
226.031677

[ Appearance of Characters ]:
lyophilized powder

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Soluble in water.

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

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