Phosphonoformic acid trisodium salt hexahydrate

Names

[ Name ]:
Phosphonoformic acid trisodium salt hexahydrate

[Synonym ]:
Phosphoranecarboxylic acid, 1,1-dihydroxy-, oxide, sodium salt, hydrate (1:3:6)
Foscarnet Sodium
Foscarnet sodium hexahydrate
Phosphonoformic acid trisodium salt hexahydrate
Sodium dioxidophosphinecarboxylate oxide hydrate (3:1:6)
Sodium phosphonatoformate hexahydrate
MFCD00150176
phosphonoformicacidtrisodiumsalthexahydrate

Biological Activity

[Description]:

Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[In Vitro]

Phosphonoformic acid inhibit the human cytomegalovirus DNA polymerase (UL54) by mimicking the pyrophosphate leaving group of the nucleotide transfer reaction[1]. Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM),HSV-1, several strains (IC50=0.4-3.5 μM)[2].

Chemical & Physical Properties

[ Boiling Point ]:
490.7ºC

[ Molecular Formula ]:
CH₁₂Na₃O₁₁P

[ Molecular Weight ]:
300.042

[ Flash Point ]:
250.6ºC

[ Exact Mass ]:
299.981018

[ PSA ]:
168.51000

[ Water Solubility ]:
H2O: 0.1 g/mL hot, clear, colorless

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SY8300000

CHEMICAL NAME :: Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt, hexahydrate

CAS REGISTRY NUMBER :: 34156-56-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8500 mg/kg/17D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 139,324,1996

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
SY8300000

Articles

Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility.

J. Virol. 89(8) , 4636-44, (2015)

DNA polymerases of the Herpesviridae and bacteriophage RB69 belong to the α-like DNA polymerase family. In spite of similarities in structure and function, the RB69 enzyme is relatively resistant to f...

Related Compounds

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