Sodium 3-methyl-2-oxobutanoate

Names

[ Name ]:
Sodium 3-methyl-2-oxobutanoate

[Synonym ]:
Butanoic acid, 3-methyl-2-oxo-, sodium salt (1:1)
MFCD00002581
EINECS 223-062-2
sodium,3-methyl-2-oxobutanoate
Butanoic acid, 3-methyl-2-oxo-, sodium salt
Sodium 3-methyl-2-oxobutanoate
3-Methyl-2-oxobutanoic acid

Biological Activity

[Description]:

Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli[1][2][3].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Sodium 3-methyl-2-oxobutanoate (alpha-Ketoisovaleric acid) is a precursor of pantothenic acid in Escherichia coli[1]. Sodium 3-methyl-2-oxobutanoate (alpha-Ketoisovaleric acid) enhances alpha-ketoisocaproic acid and alpha-keto-beta-methyl-n-valeric acid, but diminishes the corresponding amino acids, and causes an early decline of ornithine along with a late augmentation of plasma arginine[2].

[In Vivo]

Sodium 3-methyl-2-oxobutanoate (alpha-Ketoisovaleric acid) induces convulsions through GABAergic and glutamatergic mechanisms in rats[3].

[References]

[1]. MAAS WK, et al. alpha-Ketoisovaleric acid, a precursor of pantothenic acid in Escherichia coli. J Bacteriol. 1953 Apr;65(4):388-93.

[2]. Schauder P, et al. Oral administration of alpha-ketoisovaleric acid or valine in humans: blood kinetics and biochemical effects. J Lab Clin Med. 1984 Apr;103(4):597-605.

[3]. Coitinho AS, et al. Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. Brain Res. 2001 Mar 9;894(1):68-73.

Chemical & Physical Properties

[ Boiling Point ]:
170.2ºC at 760 mmHg

[ Melting Point ]:
220-230 °C (dec.)(lit.)

[ Molecular Formula ]:
C₅H₇NaO₃

[ Molecular Weight ]:
138.097

[ Exact Mass ]:
138.029282

[ PSA ]:
57.20000

[ Storage condition ]:
Store at 0-5°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2904909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Inhibition of brain energy metabolism by the alpha-keto acids accumulating in maple syrup urine disease.

Biochim. Biophys. Acta 1639(3) , 232-8, (2003)

Neurological dysfunction is a common finding in patients with maple syrup urine disease (MSUD). However, the mechanisms underlying the neuropathology of brain damage in this disorder are poorly known....

Amino acid metabolism in the human fetus at term: leucine, valine, and methionine kinetics.

Pediatr. Res. 70(6) , 566-71, (2011)

Human fetal metabolism is largely unexplored. Understanding how a healthy fetus achieves its fast growth rates could eventually play a pivotal role in improving future nutritional strategies for prema...

Direct methods and residue type specific isotope labeling in NMR structure determination and model-driven sequential assignment.

J. Biomol. NMR 42(2) , 111-27, (2008)

Direct methods in NMR based structure determination start from an unassigned ensemble of unconnected gaseous hydrogen atoms. Under favorable conditions they can produce low resolution structures of pr...

Related Compounds

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