Diethylamine NONOate diethylammonium salt

Names

[ Name ]:
Diethylamine NONOate diethylammonium salt

[Synonym ]:
1,1-Diethyl-2-hydroxy-3-oxotriazane - N-ethylethanamine (1:1)
DEA NONOate DEA NO diethylammonium salt
Diethylamine NONOate diethylammonium salt
DEA/NO diethylammonium salt
Ethanamine, N-ethyl-, compd. with 1,1-diethyl-2-hydroxy-3-oxotriazane (1:1)

Biological Activity

[Description]:

Diethylamine NONOate (DEA NONOate, diethylammonium salt) is a nitric oxide donor. Diethylamine NONOate is a potent antimicrobial agent, which can inhibit Escherichia coli growth. Diethylamine NONOate also can enhance preservation of the donor rat heart[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Sysel AM, et al. Antimicrobial properties of diethylamine NONOate, a nitric oxide donor, against Escherichia coli: a pilot study. J Antibiot (Tokyo). 2021 Apr;74(4):260-265.

[2]. Du ZY, et al. The nitric oxide donor, diethylamine NONOate, enhances preservation of the donor rat heart. J Heart Lung Transplant. 1998 Nov;17(11):1113-20.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₂₂N₄O₂

[ Molecular Weight ]:
206.29

[ Exact Mass ]:
206.174271

[ PSA ]:
75.58000

[ LogP ]:
0.31400

[ Storage condition ]:
20°C

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
C

[ Risk Phrases ]:
22-37/38-41

[ Safety Phrases ]:
26-39

[ RIDADR ]:
NONH for all modes of transport

Articles

Characterization of unusual truncated hemoglobins of Chlamydomonas reinhardtii suggests specialized functions.

Planta 242 , 167-85, (2015)

Annotated hemoglobin genes in Chlamydomonas reinhardtii form functional globins, despite unusual architectures. Spectral characteristics show subtle biochemical differences. Multiple globins might hel...

Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability.

J. Biol. Chem. 290 , 16861-72, (2015)

NADH cytochrome b5 reductase 3 (CYB5R3) is critical for reductive reactions such as fatty acid elongation, cholesterol biosynthesis, drug metabolism, and methemoglobin reduction. Although the physiolo...

Site-specific Effects of DUOX1-Related Peroxidase on Intercellular Apoptosis Signaling.

Anticancer Res. 35 , 5955-71, (2015)

Intercellular apoptosis-inducing HOCl signaling is known as an interplay between superoxide anions/H₂O₂ of transformed target cells and dual oxidase 1 (DUOX1)-related peroxidase that is released from ...

Related Compounds

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