2-Picolylamine
Names
[ CAS No. ]:
3731-51-9
[ Name ]:
2-Picolylamine
[Synonym ]:
aminomethylpyridine
2-Methyl-3-pyridinamine
2-Pyridinemethanamine
MFCD00129044
3-Amino-2-picoline
3-Pyridinamine, 2-methyl-
1-(pyridin-2-yl)methanamine
2-Picolylamine
2-(Aminomethyl)pyridine
Pyridine, 2-(aminomethyl)-
EINECS 223-090-5
2-Methylpyridin-3-amin
1-(2-Pyridinyl)methanamine
2-(Aminomethyl)pyridine;2-picolylamine
Pyridine, 2- (aminomethyl)-
N-2-Pyridylmethylamine
2-picolinamine
pyridin-2-ylmethanamine
2-aminomethyl-pyridine
2-methylpyridin-3-amine
2-Aminomethylpyridine
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
203.0±0.0 °C at 760 mmHg
[ Melting Point ]:
20°C
[ Molecular Formula ]:
C6H8N2
[ Molecular Weight ]:
108.141
[ Flash Point ]:
90.0±0.0 °C
[ Exact Mass ]:
108.068748
[ PSA ]:
24.92000
[ LogP ]:
-0.40
[ Vapour Pressure ]:
0.3±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.552
[ Water Solubility ]:
SOLUBLE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- US1840000
- CHEMICAL NAME :
- Pyridine, 2-aminomethyl-
- CAS REGISTRY NUMBER :
- 3731-51-9
- BEILSTEIN REFERENCE NO. :
- 0108054
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C6-H8-N2
- MOLECULAR WEIGHT :
- 108.16
- WISWESSER LINE NOTATION :
- T6NJ B1Z
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 340 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 26,345,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 562 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983
Safety Information
[ Symbol ]:
GHS05
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H314
[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C:Corrosive;
[ Risk Phrases ]:
R34
[ Safety Phrases ]:
S26-S36/37/39-S45-S25
[ RIDADR ]:
UN 2735 8/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
US1840000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
29333999
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933399090
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Bioorg. Med. Chem. 16 , 3530-6, (2008)
The first activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms associated to tumors, hCA IX and XII, with a small library of natural and non-natural amino acids as well as aroma...
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.Bioorg. Med. Chem. Lett. 16 , 3955-9, (2006)
The first activation study of isoform XIII of carbonic anhydrase (CA, EC 4.2.1.1) is reported. A series of amino acids and amines incorporating protonatable moieties of the primary/heterocyclic amine ...
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorg. Med. Chem. 15 , 5351-7, (2007)
The secretory isozyme of human carbonic anhydrase (hCA, EC 4.2.1.1), hCA VI, has been cloned, expressed, and purified in a bacterial expression system. The kinetic parameters for the CO(2) hydration r...