4-methylumbelliferyl α-D-galactoside

Names

[ Name ]:
4-methylumbelliferyl α-D-galactoside

[Synonym ]:
2H-1-Benzopyran-2-one, 7-(α-D-galactopyranosyloxy)-4-methyl-
4-Methyl-2-oxo-2H-chromen-7-yl α-D-galactopyranoside
4-methylumbelliferyl α-D-galactoside
4-METHYLUMBELLIFERYL-α-D-GALACTOPYRANOSIDE
MFCD00063278
EINECS 254-031-1

Biological Activity

[Description]:

4-Methylumbelliferyl-α-D-galactopyranoside (4MU-α-Gal), a substrate for α-galactosidase A (GLA), is a blue pro-fluorogenic substrate. 4-Methylumbelliferyl-α-D-galactopyranoside forms two products, galactose and fluorescent 4MU, upon cleavage by GLA[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

4-Methylumbelliferyl-α-D-galactopyranoside (4MU-α-Gal) has an emission wavelength of 440 nm and an excitation wavelength of 365 nm[1].

[References]

[1]. Omid Motabar, et al. High throughput screening for inhibitors of alpha-galactosidase. Curr Chem Genomics. 2010 Dec 3;4:67-73.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
626.9±55.0 °C at 760 mmHg

[ Melting Point ]:
171-173ºC

[ Molecular Formula ]:
C₁₆H₁₈O₈

[ Molecular Weight ]:
338.309

[ Flash Point ]:
233.9±25.0 °C

[ Exact Mass ]:
338.100159

[ PSA ]:
129.59000

[ LogP ]:
-0.46

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.641

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 10 mg/mL hot, clear, colorless

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
R26/27/28

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

A 45-kDa midgut glycoprotein from Anopheles albimanus mosquito mediates the killing of trypanosomes.

Cell Biochem. Funct. 20(3) , 257-62, (2002)

Trypanosomes do not inhabit or grow in anopheles mosquitoes, the vector for the transmission of Plasmodium parasites the causative agent for malaria. The possession of lytic factors by the anopheline ...

[A combined chromogenic-fluorogenic medium for the simultaneous detection of coliform groups and E. coli in water].

Zentralbl. Hyg. Umweltmed. 189 , 225, (1989)

A comparison was made with different chromogenic and fluorogenic substrates, 4-methylumbelliferyl-beta-D-glucuronide (MUG), 4-nitrophenyl-beta-D-glucuronide (PNPG), 4-methylumbelliferyl-beta-D-galacto...

The chaperone activity and toxicity of ambroxol on Gaucher cells and normal mice.

Brain Dev. 35(4) , 317-22, (2013)

Gaucher disease (GD), caused by a defect of acid β-glucosidase (β-Glu), is one of the most common sphingolipidoses. Recently, ambroxol, an FDA-approved drug used to treat airway mucus hypersecretion a...

Related Compounds

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