butane-2,3-dione

Names

[ CAS No. ]:
431-03-8

[ Name ]:
butane-2,3-dione

[Synonym ]:
butanedione
MFCD00008756
2,3-Butanedione
Butan-2,3-dione
EINECS 207-069-8
2,3-butandione
2,3-Butadione
Butane-2,3-dione
Biacetyl
Dimethylglyoxal
2,3-Diketobutane
Diacetyl

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
88.0±0.0 °C at 760 mmHg

[ Melting Point ]:
-4--2 °C

[ Molecular Formula ]:
C₄H₆O₂

[ Molecular Weight ]:
86.089

[ Flash Point ]:
7.2±0.0 °C

[ Exact Mass ]:
86.036781

[ PSA ]:
34.14000

[ LogP ]:
-1.33

[ Vapour density ]:
3 (vs air)

[ Vapour Pressure ]:
62.3±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.381

[ Stability ]:
Stable. Flammable. Incompatible with acids, strong bases, metals, reducing agents, oxidizing agents. Protect from moisture and water. Note low flashpoint.

[ Water Solubility ]:
200 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK2625000

CHEMICAL NAME :: 2,3-Butanedione

CAS REGISTRY NUMBER :: 431-03-8

BEILSTEIN REFERENCE NO. :: 0605398

LAST UPDATED :: 199712

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C4-H6-O2

MOLECULAR WEIGHT :: 86.10

WISWESSER LINE NOTATION :: 1VV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1580 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Vascular - regional or general arteriolar or venous dilation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 990 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 48600 mg/kg/90D-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in adrenal weight Blood - pigmented or nucleated red blood cells

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 76,809,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84595 No. of Facilities: 126 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 1503 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84595 No. of Facilities: 185 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees: 3438 (estimated) No. of Female Employees: 1628 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302-H315-H318-H331-H335

[ Precautionary Statements ]:
P210-P261-P280-P305 + P351 + P338-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;Heavyweight Gloves;multi-purpose combination respirator cartridge (US);Safety Clothing;type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R20/21/22;R36/38

[ Safety Phrases ]:
S9-S16-S26-S37/39-S36/37/39-S39

[ RIDADR ]:
UN 2346 3/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
EK2625000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2914190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914190090

[ Summary ]:
2914190090 other acyclic ketones without other oxygen function。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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Related Compounds

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