9-Phenanthrol

Names

[ CAS No. ]:
484-17-3

[ Name ]:
9-Phenanthrol

[Synonym ]:
9-Phenanthrol
Phenanthren-9-ol
MFCD00082298
EINECS 207-602-4
9-Phenanthrenol

Biological Activity

[Description]:

9-Phenanthrol (9-Hydroxyphenanthrene) is a potent and selective human TRPM4 inhibitor, with an IC50 of 20 μM. 9-Phenanthrol can be used for the research of ischemia-reperfusion injury[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Cardiovascular Disease

[References]

[1]. Wang J, et, al. 9-Phenanthrol, a TRPM4 inhibitor, protects isolated rat hearts from ischemia-reperfusion injury. PLoS One. 2013 Jul 25;8(7):e70587.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
404.5±14.0 °C at 760 mmHg

[ Melting Point ]:
139-143ºC

[ Molecular Formula ]:
C₁₄H₁₀O

[ Molecular Weight ]:
194.23

[ Flash Point ]:
197.7±12.0 °C

[ Exact Mass ]:
194.073166

[ PSA ]:
20.23000

[ LogP ]:
3.94

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.754

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SF8288000

CHEMICAL NAME :: 9-Phenanthrol

CAS REGISTRY NUMBER :: 484-17-3

BEILSTEIN REFERENCE NO. :: 2047057

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H10-O

MOLECULAR WEIGHT :: 194.24

WISWESSER LINE NOTATION :: L B666J HQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - hamster Kidney

DOSE/DURATION :: 5 mg/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 20,1297,1971

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
SF8288000

[ HS Code ]:
2906299090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2906299090

[ Summary ]:
2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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Related Compounds

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