Monoctanoin

Names

[ CAS No. ]:
502-54-5

[ Name ]:
Monoctanoin

[Synonym ]:
1-Octanoyl-rac-glycerol
MONOCAPRYLIN
1-Capryloyl-rac-glycerol Monocaprylin

Biological Activity

[Description]:

Glyceryl 1-monooctanoate is a glycerol monolaurate derivative. Glyceryl 1-monooctanoate is a broad-spectrum antimicrobial, suppresses the growth of pathogenic yeast (Candida albicans and Candida parapsilosis), as well as Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) bacteria[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Glyceryl 1-monooctanoate (0-32.5 mg/L; 30 d) has antifungal activity against saprophytic fungi. Glyceryl 1-monooctanoate inhibits the growth of Aspergillus niger, Penicillium roqueforti, Penicillium jensenii, Alternaria sp., Phoma sp[1]. Glyceryl 1-monooctanoate (0-32.5 mg/L; 30 d) has antifungal activity against pathogenic fungi. Glyceryl 1-monooctanoate inhibits the growth of Trichophyton mentagrophytes and Trichophyton rubrum[1]. Glyceryl 1-monooctanoate (30 d) has antifungal activity against pathogenic yeast with minimum inhibitory concentration (MIC) of 200 mg/L for Candida albicans[1]. Glyceryl 1-monooctanoate (30 d) has antifungal activity against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) bacteria[1].

[References]

[1]. Vltavska´ P, et, al. Antifungal and antibacterial effects of 1-monocaprylin on textile materials. Eur. J. Lipid Sci. Technol. 2012.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₂₂O₄

[ Molecular Weight ]:
218.29000

[ Exact Mass ]:
218.15200

[ PSA ]:
66.76000

[ LogP ]:
1.24330

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

How relevant are assembled equilibrium samples in understanding structure formation during lipid digestion?

Eur. J. Pharm. Biopharm. 96 , 117-24, (2015)

Lipid-based formulations are gaining interest for use as drug delivery systems for poorly water-soluble drug compounds. During digestion, the lipolysis products self-assemble with endogenous surfactan...

Transcutaneous delivery of leflunomide nanoemulgel: Mechanistic investigation into physicomechanical characteristics, in vitro anti-psoriatic and anti-melanoma activity.

Int. J. Pharm. 487 , 148-56, (2015)

The present study is a mechanistic validation of 'proof of concept' of effective topical delivery of leflunomide (LFD) nanoemulgel for localized efficient treatment of psoriatic lesions as well as mel...

Solid self-nanoemulsifying drug delivery system (S-SNEDDS) of darunavir for improved dissolution and oral bioavailability: In vitro and in vivo evaluation.

Eur. J. Pharm. Sci. 74 , 1-10, (2015)

The current study was aimed to investigate the potential of solid self-nanoemulsifying drug delivery system (S-SNEDDS) composed of Capmul MCM C8 (oil), Tween 80 (surfactant) and Transcutol P (co-surfa...

Related Compounds

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