8-Br-cGMP(8-Bromo-cGMP)

Names

[ Name ]:
8-Br-cGMP(8-Bromo-cGMP)

[Synonym ]:
8-Br-cGMP 8-Bromo-cyclic GMP
EINECS 256-993-8
sodium 8-bromo-3',5'-cyclic GMP
Sodium (4aR,6R,7R,7aS)-6-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide
8-Bromo-cGMP, sodium salt,8-Bromoguanosinecyclic3',5'-monophosphatesodiumsalt
6H-Purin-6-one, 2-amino-8-bromo-1,9-dihydro-9-[(4aR,6R,7R,7aS)-tetrahydro-2,7-dihydroxy-2-oxido-4H-furo[3,2-d]-1,3,2-dioxaphosphorin-6-yl]-, sodium salt (1:1)
MFCD00070128

Biological Activity

[Description]:

8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator and significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+[1]. 8-Bromo-cGMP sodium has antinociceptive effects[2].

[Target]

PKG, Ca2+[1]

[References]

[1]. Sarkar O , et al. Nitric oxide attenuates overexpression of Giα proteins in vascular smooth muscle cells from SHR: Role of ROS and ROS-mediated signaling. PLoS One. 2017 Jul 10;12(7):e0179301.

[2]. Tegeder I , et al. Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Neurosci Lett. 2002 Oct 31;332(2):146-50.

Chemical & Physical Properties

[ Density]:
2.96 g/cm3

[ Boiling Point ]:
794.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₀BrN₅NaO₇P

[ Molecular Weight ]:
446.083

[ Flash Point ]:
434.2ºC

[ Exact Mass ]:
444.939880

[ PSA ]:
187.45000

[ LogP ]:
0.25780

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension.

PLoS ONE 10 , e0134876, (2015)

Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-c...

Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice.

Br. J. Pharmacol. 171(24) , 5858-69, (2014)

Caffeine is one of the most commonly used psychoactive substances. Circadian rhythms consist of the main suprachiasmatic nucleus (SCN) clocks and peripheral clocks. Although caffeine lengthens circadi...

Platelet-derived HMGB1 is a critical mediator of thrombosis.

J. Clin. Invest. 125 , 4638-54, (2015)

Thrombosis and inflammation are intricately linked in several major clinical disorders, including disseminated intravascular coagulation and acute ischemic events. The damage-associated molecular patt...

Related Compounds

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