NH2-C6-NH-Boc

Names

[ Name ]:
NH2-C6-NH-Boc

[Synonym ]:
N-(tert-Butoxycarbonyl)-1,6-diaminohexane
N-Boc-1,6-hexanediamine
tert-Butyl (6-aminohexyl)carbamate
N-Boc-1,6-Diaminohexane
N-(6-Aminohexyl)carbamic Acid tert-Butyl Ester
tert-butyl N-(6-aminohexyl)carbamate
Carbamic acid, N-(6-aminohexyl)-, 1,1-dimethylethyl ester
MFCD00671489
2-Methyl-2-propanyl (6-aminohexyl)carbamate
N-(tert-Butoxycarbonyl)-1,6-hexanediamine

Biological Activity

[Description]:

NH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[References]

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
325.3±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₂₄N₂O₂

[ Molecular Weight ]:
216.320

[ Flash Point ]:
150.5±23.2 °C

[ Exact Mass ]:
216.183777

[ PSA ]:
64.35000

[ LogP ]:
1.82

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.460

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2735 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Carboxymethylcellulose-tetrahydrocurcumin conjugates for colon-specific delivery of a novel anti-cancer agent, 4-amino tetrahydrocurcumin.

Eur. J. Pharm. Biopharm. 88(2) , 351-60, (2014)

Several curcumin derivatives are now becoming increasingly of interest because of their bioactive attributes, especially their action as antioxidants and anti-carcinogenic activities. Tetrahydrocurcum...

Structure-activity relationships of novel vasopressin antagonists containing C-terminal diaminoalkanes and (aminoalkyl)guanidines.

J. Med. Chem. 32 , 391, (1989)

We report the synthesis and biological activity of a series of analogues of the vasopressin antagonists [Pmp1,D-Tyr(Et)2,Val4]arginine-vasopressin (1) and [Pmp1,D-Tyr(Et)2,Val4,desGly9]arginine-vasopr...

O. Buchardt et al.

J. Org. Chem. 49 , 4123, (1984)

Related Compounds

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