1,2,4-Trihydroxybenzene
Names
[ CAS No. ]:
533-73-3
[ Name ]:
1,2,4-Trihydroxybenzene
[Synonym ]:
4-Hydroxycatechol
1,2,4-Trihydroxybenzene
1,2,4-Benzenetriol
1,3,4-Benzenetriol
1,2,3-Trihydroxybenzene
benzene-1,2,3-triol
EINECS 208-575-1
Hydroxyhydroquinone
Benzene-1,2,4-triol
Benzol-1,2,3-triol
1,2,3-Benzenetriol
gallol
4-06-00-07338 (Beilstein Handbook Reference)
MFCD00002198
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
334.5±12.0 °C at 760 mmHg
[ Melting Point ]:
140 °C (subl.)(lit.)
[ Molecular Formula ]:
C6H6O3
[ Molecular Weight ]:
126.110
[ Flash Point ]:
176.9±14.2 °C
[ Exact Mass ]:
126.031693
[ PSA ]:
60.69000
[ LogP ]:
0.06
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.677
[ Water Solubility ]:
freely soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DC4200000
- CHEMICAL NAME :
- 1,2,4-Benzenetriol
- CAS REGISTRY NUMBER :
- 533-73-3
- BEILSTEIN REFERENCE NO. :
- 2042863
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C6-H6-O3
- MOLECULAR WEIGHT :
- 126.12
- WISWESSER LINE NOTATION :
- QR BQ DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 122 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 10 umol/L
- REFERENCE :
- EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 82,81,1989
Safety Information
[ Symbol ]:
GHS05, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H315-H318-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R20/21/22;R36/37/38
[ Safety Phrases ]:
S26-S39-S36/37/39-S22
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
DC4200000
[ HS Code ]:
2907299090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2907299090
[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%
Articles
J. Dermatol. Sci. 80 , 18-24, (2015)
Tyrosinase is able to oxidize a great number of phenols and catechols to form ortho-quinones. Ortho-quinones are highly reactive compounds that exert cytotoxicity through binding with thiol enzymes an...
Degradation of sulfonamide antibiotics by Microbacterium sp. strain BR1 - elucidating the downstream pathway.New Biotechnology 32 , 710-5, (2015)
Microbacterium sp. strain BR1 is among the first bacterial isolates which were proven to degrade sulfonamide antibiotics. The degradation is initiated by an ipso-substitution, initiating the decay of ...
The TetR-type transcriptional repressor RolR from Corynebacterium glutamicum regulates resorcinol catabolism by binding to a unique operator, rolO.Appl. Environ. Microbiol. 78(17) , 6009-16, (2012)
The rol (designated for resorcinol) gene cluster rolRHMD is involved in resorcinol catabolism in Corynebacterium glutamicum, and RolR is the TetR-type regulator. In this study, we investigated how Rol...