1,3-Dichloroacetone
Names
[ CAS No. ]:
534-07-6
[ Name ]:
1,3-Dichloroacetone
[Synonym ]:
2-Propanone, 1,3-dichloro-
1,3-Dichloropropan-2-one
MFCD00000937
1,3-Dichloroacetone
monochloromethyl ketone
1,3-dichloropropanone
EINECS 208-585-6
4,4'-Dimethoxystilbendichlorid
1,3-dichloro acetone
1,3-dichloro-2-propanone
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
173.0±0.0 °C at 760 mmHg
[ Melting Point ]:
43 °C
[ Molecular Formula ]:
C3H4Cl2O
[ Molecular Weight ]:
126.969
[ Flash Point ]:
89.4±0.0 °C
[ Exact Mass ]:
125.963921
[ PSA ]:
17.07000
[ LogP ]:
1.29
[ Vapour density ]:
4.38 (vs air)
[ Vapour Pressure ]:
1.3±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.437
[ Water Solubility ]:
27.9 g/L (20 º C)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UC1430000
- CHEMICAL NAME :
- 2-Propanone, 1,3-dichloro-
- CAS REGISTRY NUMBER :
- 534-07-6
- BEILSTEIN REFERENCE NO. :
- 0605456
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 23
- MOLECULAR FORMULA :
- C3-H4-Cl2-O
- MOLECULAR WEIGHT :
- 126.97
- WISWESSER LINE NOTATION :
- G1V1G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 29 mg/m3/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18900 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27 mg/m3/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 53 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - iritis Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 720 mg/kg/90D-C
- TOXIC EFFECTS :
- Behavioral - fluid intake Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 37500 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 2 umol/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993
Safety Information
[ Symbol ]:
GHS05, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300 + H310 + H330-H314-H341
[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P302 + P350
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T+:Verytoxic;
[ Risk Phrases ]:
R24;R26/28;R36/37/38;R68
[ Safety Phrases ]:
S26-S36/37/39-S45-S28A-S1
[ RIDADR ]:
UN 3286 3/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
UC1430000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
[ HS Code ]:
29147090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914700090
[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%
Articles
Reprod. Toxicol. 28(4) , 503-10, (2009)
The chick micromass culture system has advantages over the validated rat system – ready availability and non-culling of the donor parent – but needs to give comparable results. This study confirmed co...
In vitro metabolism and bioactivation of 1,2,3-trichloropropane.Toxicol. Appl. Pharmacol. 113(1) , 152-8, (1992)
In vitro studies using rat and human hepatic microsomes have shown that the halogenated hydrocarbon 1,2,3-trichloropropane (TCP) is bioactivated to the direct acting mutagen 1,3-dichloroacetone (DCA)....
Effects of pH and temperature on the degradation of chloroacetones that are mutagenic.Bull. Environ. Contam. Toxicol. 39(3) , 549-54, (1987)