1,4-Phenylenedimethanamine
Names
[ CAS No. ]:
539-48-0
[ Name ]:
1,4-Phenylenedimethanamine
[Synonym ]:
p-Xylene Diamine
1,4-Benzenedimethanamine (9IC)
1,4-Bis(aminomethyl)benzene
benzene-1,4-diyldimethanamine
MFCD00009821
α,α'-Diamino-p-xylene
4-(Aminomethyl)benzylamine
p-XylylenediaMine
1,4-Benzenedimethanamine
α,α′-diamino-p-xylene
1,4-Phenylenedimethanamine
EINECS 208-719-3
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
261.9±20.0 °C at 760 mmHg
[ Melting Point ]:
60-63 °C(lit.)
[ Molecular Formula ]:
C8H12N2
[ Molecular Weight ]:
136.194
[ Flash Point ]:
131.8±21.3 °C
[ Exact Mass ]:
136.100052
[ PSA ]:
52.04000
[ LogP ]:
-0.04
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.581
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- PF9000000
- CHEMICAL NAME :
- Methylamine, p-phenylenebis-
- CAS REGISTRY NUMBER :
- 539-48-0
- BEILSTEIN REFERENCE NO. :
- 2206190
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C8-H12-N2
- MOLECULAR WEIGHT :
- 136.22
- WISWESSER LINE NOTATION :
- Z1R D1Z
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,448,1986
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,448,1986
Safety Information
[ Symbol ]:
GHS05
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H314
[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
C:Corrosive;
[ Risk Phrases ]:
R34
[ Safety Phrases ]:
S26-S36/37/39-S45
[ RIDADR ]:
UN 3259 8/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
PF9000000
[ Packaging Group ]:
II
[ Hazard Class ]:
8
[ HS Code ]:
2921590090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921590090
[ Summary ]:
2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Bioorg. Med. Chem. Lett. 19 , 6326-30, (2009)
Three dendritic polyphenols (generation 1) were synthesized: a syringaldehyde-based dendrimer (1), a vanillin-based dendrimer (2), and an iodinated vanillin-based dendrimer (3). They all showed strong...
New efficient substrates for semicarbazide-sensitive amine oxidase/VAP-1 enzyme: analysis by SARs and computational docking.J. Med. Chem. 49 , 6197-208, (2006)
Structure activity relationships for semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) were studied using a library of arylalkylamine substrates, with the aim of contribut...
Discovery of small molecule CXCR4 antagonists.J. Med. Chem. 50 , 5655-5664, (2007)
In light of a proposed molecular mechanism for the C-X-C chemokine receptor type 4 (CXCR4) antagonist 1 (AMD3100), a template with the general structure 2 was designed, and 15 was identified as a lead...