metoclopramide hydrochloride

Names

[ Name ]:
metoclopramide hydrochloride

[Synonym ]:
Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-, monohydrochloride (9CI)
Annavar
4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide monohydrochloride
4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide monohydrochloride
Benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-, hydrochloride (1:1)
4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride (1:1)
Metoclopramide hydrochloride [USAN:JAN]
4-Amino-5-chlor-N-[2-(diethylamino)ethyl]-2-methoxybenzolcarboxamidhydrochlorid
o-Anisamide, 4-amino-5-chloro-N-[2- (diethylamino)ethyl]-, monohydrochloride
GastreseL.A
4-amino-5-chloro-N-[2-(diéthylamino)éthyl]-2-méthoxybenzamide chlorhydrate
Benzamide, 4-amino-5-chloro-N-[2- (diethylamino)ethyl]-2-methoxy-, monohydrochloride
Metoclopramide Hydrochloride (500 mg)
4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-o-anisamide hydrochloride
MFCD00150634
benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-, monohydrochloride
METOCLOPRAMIDEHYDROCHLORIDE,MONOHYDRATE,USP
MetoclopraMide HCI
Gastromax
4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide hydrochloride
metoclopramide monohydrochloride
Gastrobidcontinus
EINECS 230-634-5
MetoclopraMide Hydrochloride,USP
Metoclopramide hydrochloride
4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide hydrochloride
Metoclopramide (hydrochloride hydrate)

Biological Activity

[Description]:

Metoclopramide hydrochloride hydrate is a dopamine D2 antagonist that is used as an antiemetic.IC50 Value:Target: D2 ReceptorMetoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Endocrinology

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
418.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₂₅Cl₂N₃O₃

[ Molecular Weight ]:
354.27

[ Flash Point ]:
207ºC

[ PSA ]:
67.59000

[ LogP ]:
3.77650

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Articles

Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates.

Drug Metab. Pharmacokinet. 29(5) , 419-26, (2014)

In central nervous system drug discovery, cerebrospinal fluid (CSF) drug concentration (C(CSF)) has been widely used as a surrogate for unbound brain concentrations (C(u,brain)). However, previous rod...

Clinical challenge. Esophageal hiatal hernia.

J. Zoo Wildl. Med. 45(4) , 999-1001, (2014)

The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis.

Am. J. Gastroenterol. 108(9) , 1382-91, (2013)

The relationship between symptom improvement (SI) and acceleration of gastric emptying (GE) for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain. In this pap...

Related Compounds

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