Ammonium thioglycolate
Names
[ CAS No. ]:
5421-46-5
[ Name ]:
Ammonium thioglycolate
[Synonym ]:
azanium,2-sulfanylacetate
MFCD00137451
EINECS 226-540-9
Chemical & Physical Properties
[ Density]:
1.311g/cm3
[ Boiling Point ]:
115ºC
[ Melting Point ]:
-10ºC
[ Molecular Formula ]:
C2H7NO2S
[ Molecular Weight ]:
109.14700
[ Flash Point ]:
99.8ºC
[ Exact Mass ]:
109.02000
[ PSA ]:
78.93000
[ Water Solubility ]:
Miscible
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AI7525000
- CHEMICAL NAME :
- Acetic acid, mercapto-, monoammonium salt
- CAS REGISTRY NUMBER :
- 5421-46-5
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C2-H4-O2-S.H3-N
- MOLECULAR WEIGHT :
- 109.16
- WISWESSER LINE NOTATION :
- SH1VO &ZH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 165 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 97,349,1949
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 175 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 97,349,1949
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 97,349,1949 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83494 No. of Facilities: 4049 (estimated) No. of Industries: 4 No. of Occupations: 3 No. of Employees: 33142 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83494 No. of Facilities: 4016 (estimated) No. of Industries: 6 No. of Occupations: 5 No. of Employees: 41131 (estimated) No. of Female Employees: 30870 (estimated)
Safety Information
[ Symbol ]:
GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H290-H301-H317
[ Precautionary Statements ]:
P280-P301 + P310
[ Personal Protective Equipment ]:
Eyeshields;Gloves
[ Hazard Codes ]:
T
[ Risk Phrases ]:
25-43
[ Safety Phrases ]:
36/37-45
[ RIDADR ]:
2810
[ WGK Germany ]:
1
[ RTECS ]:
AI7525000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
Articles
Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(1) , R35-43, (2014)
β-mercaptoacetate (MA) is a drug known to block mitochondrial oxidation of medium- and long-chain fatty acids (FAs) and to stimulate feeding. Because MA-induced feeding is vagally dependent, it has be...
Preactivated thiomers for vaginal drug delivery vehicles.Biomaterials 34(32) , 7811-8, (2013)
It was the purpose of this study to design and evaluate a chitosan derivative as mucoadhesive excipient for vaginal drug delivery systems. The chemical modification of chitosan was achieved by conjuga...