Metalaxyl

Names

[ Name ]:
Metalaxyl

[Synonym ]:
Apron 35WS
Methyl 2-[(2,6-dimethylphenyl)(methoxyacetyl)amino]propanoate
Bleu
Methyl N-(2-methoxyacetyl)-N-(2,6-xylyl)-D-alaninate
Apron TL
MILOR
MFCD00055447
2-[(2,6-Dimethylphenyl)-(2-methoxyacetyl)amino]propionic acid methyl ester
cg117
Metalaxyl
Subdue
1OVY1&NV1O1&R B1 F1 &&(RS)- or DL- Form
INFRA
1OVY1&NV1O1&R B1 F1 &&(RS) Form
Apron 35J
APRON
methyl N-(methoxyacetyl)-N-2,6-xylyl-DL-alaninate
Apron 350FW
Fubol
TOKAT
EINECS 260-979-7
N-(2,6-Dimethylphenyl)-N-(methoxyacetyl)-DL-alanine methyl ester
Metaxanine
SPAN
Alanine, N-(2,6-dimethylphenyl)-N-(2-methoxyacetyl)-, methyl ester
METAX
Alanine, N-(methoxyacetyl)-N-(2,6-xylyl)-, methyl ester, DL-
N-(2,6-Dimethylphenyl)-N-(methoxyacetyl)alanine methyl ester
Methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate
Methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)-DL-alaninate

Biological Activity

[Description]:

Metalaxyl is a fungicide that inhibits protein synthesis in fungi. Metalaxyl inhibits the growth of potato blight (P. infestans) fungal isolates from Serbian potato fields (EC50s = 0.3-3.9 μg/mL).

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Fungal

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
394.3±42.0 °C at 760 mmHg

[ Melting Point ]:
72-73°C

[ Molecular Formula ]:
C₁₅H₂₁NO₄

[ Molecular Weight ]:
279.332

[ Flash Point ]:
192.3±27.9 °C

[ Exact Mass ]:
279.147064

[ PSA ]:
55.84000

[ LogP ]:
2.15

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.528

[ Water Solubility ]:
0.84 g/100 mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY6910000

CHEMICAL NAME :: Alanine, N-(methoxyacetyl)-N-(2,6-xylyl)-, methyl ester, DL-

CAS REGISTRY NUMBER :: 57837-19-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H21-N-O4

MOLECULAR WEIGHT :: 279.37

WISWESSER LINE NOTATION :: 1OVY1&NV1O1&R B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 566 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 300 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 369,81,1996 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H317-H412

[ Precautionary Statements ]:
P273-P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R43;R52/53

[ Safety Phrases ]:
S13-S24-S37-S46-S61-S36-S26-S16

[ RIDADR ]:
UN 1648 3/PG 2

[ RTECS ]:
AY6910000

[ HS Code ]:
2924299034

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299034

[ Summary ]:
2924299034 n-(3-chloro-4-methylphenyl)-2-methylpentanamide。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

Articles

Unequivocal Enantiomeric Identification and Analysis of 10 Chiral Pesticides in Fruit and Vegetables by QuEChERS Method Combined With Liquid Chromatography-Quadruple/Linear Ion Trap Mass Spectrometry Determination.

Chirality 27 , 958-64, (2015)

In this research, 10 chiral pesticides in fruits and vegetables were simultaneously determined using chiral liquid chromatography triple quadrupole-linear ion trap hybrid mass spectrometry (LC-QqLIT)....

Dissipation and residue of metalaxyl and cymoxanil in pepper and soil.

Environ. Monit. Assess. 186(8) , 5307-13, (2014)

A simple and accurate method of determining metalaxyl and cymoxanil in pepper and soil was developed by ultra-performance liquid chromatography-photodiode array detection. The limits of detection were...

Nematicides enhance growth and yield of rotylenchulus reniformis resistant cotton genotypes.

J. Nematol. 46(4) , 365-75, (2015)

Rotylenchulus reniformis resistant LONREN-1×FM966 breeding lines developed at Auburn University have demonstrated that the nematode resistance is accompanied by severe stunting, limited growth, and lo...

Related Compounds

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