Guanidine thiocyanate

Names

[ CAS No. ]:
593-84-0

[ Name ]:
Guanidine thiocyanate

[Synonym ]:
GUANIDINE RHODANIDE
Guanidine, thiocyanate (1:1)
Guandine thiocyanate
thiocyanic acid,guanidine salt
Guanidinethiocyanate
GUANIDINIUM RHODANIDE
MFCD00013027
Guanidine isothiocyanate
Guanidine thiocyanate
Guanidine thiocyanate (1:1)
Guanidine thiocyanat
Guanidinium thiocyanate
GdmSCN
guanidine monothiocyanate
usafek-705
GTC
Guanidiniumthiocyanat
EINECS 209-812-1

Biological Activity

[Description]:

Guanidine thiocyanate is a chaotropic agent. Guanidine thiocyanate can be used as a protein denaturant and a nucleic acid protector in the extraction of DNA and RNA from cells[1].

[Related Catalog]:

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Mason PE, et al. The hydration structure of guanidinium and thiocyanate ions: implications for protein stability in aqueous solution. Proc Natl Acad Sci U S A. 2003;100(8):4557-4561.

Chemical & Physical Properties

[ Density]:
1.103 g/mL at 20 °C

[ Boiling Point ]:
132.9ºC at 760 mmHg

[ Melting Point ]:
120-122 °C(lit.)

[ Molecular Formula ]:
C₂H₆N₄S

[ Molecular Weight ]:
118.16

[ Flash Point ]:
34.2ºC

[ Exact Mass ]:
118.031319

[ PSA ]:
138.48000

[ LogP ]:
0.73618

[ Index of Refraction ]:
n20/D 1.482

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stability Stable, but light sensitive. Incompatible with acids (contact releases very toxic gas), strong oxidising agents.

[ Water Solubility ]:
H2O: 6 M at 20 °C, clear, colorless

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XL1225000

CAS REGISTRY NUMBER :: 593-84-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C-H5-N3.C-H-N-S

MOLECULAR WEIGHT :: 118.18

WISWESSER LINE NOTATION :: ZYZUM &SHCN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302 + H312 + H332-H314-H412

[ Supplemental HS ]:
Contact with acids liberates very toxic gas.

[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R32;R52/53

[ Safety Phrases ]:
S36/37-S61-S13

[ RIDADR ]:
1759

[ WGK Germany ]:
2

[ RTECS ]:
XL1225000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2925290090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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Related Compounds

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