8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol
Names
[ CAS No. ]:
59468-85-8
[ Name ]:
8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol
[Synonym ]:
8-Chloro-6-(2-fluorophenyl)-4-hydroxy-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
8-Chloro-6-(2-fluorophenyl)-4-hydroxy-4H-imidazo[1,5a][1,4]bezodiazepine
4-OH-Mdz
4-hydroxy-MDZ
8-chloro-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-4-ol
4-Hydroxy Midazolam
Chemical & Physical Properties
[ Density]:
1.44g/cm3
[ Boiling Point ]:
550.6ºC at 760 mmHg
[ Melting Point ]:
186-187ºC
[ Molecular Formula ]:
C18H13ClFN3O
[ Molecular Weight ]:
341.76700
[ Flash Point ]:
286.8ºC
[ Exact Mass ]:
341.07300
[ PSA ]:
50.41000
[ LogP ]:
3.25070
[ Index of Refraction ]:
1.688
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Biochem. Pharmacol. 92(4) , 701-11, (2014)
The hepatic cytochrome P450 reductase null (HRN) mouse, which has no functional hepatic Cyp P450s, may represent a useful model for examining extra-hepatic P450-related oxidative metabolism. Here the ...
Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.J. Chromatogr. A. 1374 , 122-33, (2014)
The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab...
Species differences and substrate specificity of CYP3A heteroactivation by efavirenz.Xenobiotica 45(4) , 345-52, (2015)
1. The purpose of this study was to clarify species differences in the heteroactivation of CYP3A substrates by efavirenz, which is known from clinical studies to activate midazolam 1'-hydroxylation, a...