2-Chloropropanoic acid
Names
[ CAS No. ]:
598-78-7
[ Name ]:
2-Chloropropanoic acid
[Synonym ]:
QVYG1
2-Chloropropionicacid
2-Chloropropanoic acid
2-chloro-propionicaci
EINECS 209-952-3
2-Chloropropionic ac
Propionic acid, α-chloro-
RARECHEM AL BO 1240
2-chloropropionic
2-chloro-propanoicaci
Propanoic acid, 2-chloro-
MFCD00004224
α-Monochloropropanoic acid
2-Chlorpropionsure
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
189.0±13.0 °C at 760 mmHg
[ Melting Point ]:
-12--14 °C
[ Molecular Formula ]:
C3H5ClO2
[ Molecular Weight ]:
108.524
[ Flash Point ]:
101.7±0.0 °C
[ Exact Mass ]:
107.997810
[ PSA ]:
37.30000
[ LogP ]:
0.30
[ Vapour Pressure ]:
0.3±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.441
[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong bases.
[ Water Solubility ]:
freely soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UE8575000
- CHEMICAL NAME :
- Propionic acid, 2-chloro-
- CAS REGISTRY NUMBER :
- 598-78-7
- BEILSTEIN REFERENCE NO. :
- 1720259
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C3-H5-Cl-O2
- MOLECULAR WEIGHT :
- 108.53
- WISWESSER LINE NOTATION :
- QVYG1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria Skin and Appendages - hair
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555355
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria Skin and Appendages - hair
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555355
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 126 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 5,136(89),1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7182 mg/kg/42D-C
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of esophagus Skin and Appendages - hair Related to Chronic Data - changes in testicular weight
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555355 *** REVIEWS *** ACGIH TLV-TWA 0.44 mg/m3 (0.1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 2 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
Safety Information
[ Symbol ]:
GHS05, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H314
[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C:Corrosive
[ Risk Phrases ]:
R21/22;R35
[ Safety Phrases ]:
S23-S26-S28-S36-S45-S36/37/39-S28A
[ RIDADR ]:
UN 2511 8/PG 3
[ WGK Germany ]:
1
[ RTECS ]:
UE8575000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
29159080
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 29159080
Articles
Eur. J. Biochem. 250(3) , 789-93, (1997)
A 3-kb EcoRI fragment of genomic DNA from a Rhizobium sp. cloned into pUC19 endowed Escherichia coli K-12 with the ability to grow, albeit slowly, with 2-chloropropionic acid as substrate. The constru...
Direct determination of the enantiomeric purity or enantiomeric composition of methylpropionates using a single capacitive microsensor.Anal. Chem. 81(5) , 1969-75, (2009)
Capacitive enantioselective sensors have been demonstrated to provide antipodal signals upon dosage of, e.g., the enantiomers of methyl lactate or methyl-2-chloropropionate. In a next step, these sens...
Use of structure-activity relationships for probing biochemical mechanisms: glutathione transferase zeta conjugation of haloacids.Adv. Exp. Med. Biol. 500 , 23-31, (2001)