Sesamin

Names

[ CAS No. ]:
607-80-7

[ Name ]:
Sesamin

[Synonym ]:
Sesamin
(7S,7’S,8R,8’R)-sesamin
5,5'-(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(1,3-benzodioxole)
(+)-Sesamin
Pseudocubebin
d-Sesamin
SesameP.E.
SezaMin
1,3-Benzodioxole, 5,5'-[(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis-
FAGAROL

Biological Activity

[Description]:

Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

delta 5 desaturase[1]

[In Vitro]

Pretreated with sesamin, Excess generation of nitric oxide in lipopolysaccharide-stimulated rat primary microglia cells was significantly attenuated[1].

[In Vivo]

Sesamin (o.p.; 20 mg/kg/day) significantly reduces the infarct size by approximately 50% in male gerbils (60-85 g)[1].

[References]

[1]. Cheng FC, et al. Neuroprotective effects of sesamin and sesamolin on gerbil brain in cerebral ischemia. Int J Biomed Sci. 2006 Sep;2(3):284-8.

[2]. Shimizu S, et al. Sesamin is a potent and specific inhibitor of delta 5 desaturase in polyunsaturated fatty acidbiosynthesis. Lipids. 1991 Jul;26(7):512-6.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
504.4±50.0 °C at 760 mmHg

[ Melting Point ]:
122-124ºC

[ Molecular Formula ]:
C₂₀H₁₈O₆

[ Molecular Weight ]:
354.353

[ Flash Point ]:
212.3±30.0 °C

[ Exact Mass ]:
354.110352

[ PSA ]:
55.38000

[ LogP ]:
3.32

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.623

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition.

Sci. Rep. 4 , 5896, (2014)

Dysfunctions of the mitochondria and the ubiquitin-proteasome system, as well as generation of reactive oxygen species (ROS), are linked to many aging-related neurodegenerative disorders. However, the...

Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.).

Mol. Biol. Rep. 39(6) , 6867-73, (2012)

Metabolic transformations of two substrates for human cytochrome P450 (CYP450) 2C9, tolbutamide and diclofenac, were investigated in hepatic microsomes from Atlantic salmon (Salmo salar L.). Tolbutami...

Influence of oral supplementation with sesamin on longevity of Caenorhabditis elegans and the host defense.

Eur. J. Nutr. 53(8) , 1659-68, (2014)

Nutritional control has been proposed as a potential therapy for slowing the senescence of immune function and decreasing mortality. This study investigated whether sesamin could modify host defense s...

Related Compounds

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