Glycerol-d5

Names

[ Name ]:
Glycerol-d5

[Synonym ]:
1,1,2,3,3-D5-glycerol
Bulbold-d5
Osmoglyn-d5
1,1,2,3,3-pentadeuterio-propane-1,2,3-triol
Glycerin-d5
MFCD00084148
Glyceritol-d5
Propanetriol-d5
Glysanin-d5
Glycerol-1,1,2,3,3-d5
glycerol-d5
Glycerine-d5

Biological Activity

[Description]:

Glycerol-d5 is the deuterium labeled Glycerol[1]. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[2][3][4].

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Pennings S, et al. Effect of glycerol on the separation of nucleosomes and bent DNA in low ionic strengthpolyacrylamide gel electrophoresis. Nucleic Acids Res. 1992 Dec 25;20(24):6667-72.

[3]. Yazdani SS, et al. Anaerobic fermentation of glycerol: a path to economic viability for the biofuelsindustry. Curr Opin Biotechnol. 2007 Jun18(3):213-9.

[4]. Huang ZH, et al. Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure. Eur J Pharmacol. 2000 Oct 20406(3):453-60.

Chemical & Physical Properties

[ Density]:
1.331 g/mL at 25ºC

[ Boiling Point ]:
182ºC(lit.)

[ Melting Point ]:
20ºC(lit.)

[ Molecular Formula ]:
C₃H₃D₅O₃

[ Molecular Weight ]:
97.12460

[ Flash Point ]:
320 °F

[ Exact Mass ]:
97.07870

[ PSA ]:
60.69000

[ Index of Refraction ]:
n20/D 1.472(lit.)

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Anomalously large isotope effect in the glass transition of water.

Proc. Natl. Acad. Sci. U. S. A. 111(49) , 17402-7, (2014)

We present the discovery of an unusually large isotope effect in the structural relaxation and the glass transition temperature Tg of water. Dielectric relaxation spectroscopy of low-density as well a...

Production and characterization of recombinant perdeuterated cholesterol oxidase.

Anal. Biochem. 485 , 102-8, (2015)

Cholesterol oxidase (CO) is a FAD (flavin adenine dinucleotide) containing enzyme that catalyzes the oxidization and isomerization of cholesterol. Studies directed toward elucidating the catalytic mec...

Quantitative 3D molecular cutaneous absorption in human skin using label free nonlinear microscopy.

J. Control. Release 200 , 78-86, (2015)

Understanding the penetration mechanisms of drugs into human skin is a key issue in pharmaceutical and cosmetics research. To date, the techniques available for percutaneous penetration of compounds f...

Related Compounds

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