1,3-Dioxolane
Names
[ CAS No. ]:
646-06-0
[ Name ]:
1,3-Dioxolane
[Synonym ]:
1.3-dioxolane
1,4-dioxolane
1,3-Dioxolan
1,3-dioxalane
Formal glycol
MFCD00003207
ethylene glycol methylene ether
trans dioxolane
ethylene glycol formal
EINECS 211-463-5
cis dioxolane
dioxolane, 1,3-
1,3-dioxacyclopentane
Glycol formal
1,3-Dioxolane
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
75.6±0.0 °C at 760 mmHg
[ Melting Point ]:
−95 °C(lit.)
[ Molecular Formula ]:
C3H6O2
[ Molecular Weight ]:
74.078
[ Flash Point ]:
1.7±0.0 °C
[ Exact Mass ]:
74.036781
[ PSA ]:
18.46000
[ LogP ]:
-0.73
[ Vapour density ]:
2.6 (vs air)
[ Vapour Pressure ]:
114.6±0.1 mmHg at 25°C
[ Index of Refraction ]:
1.397
[ Stability ]:
Below 4°C
[ Water Solubility ]:
SOLUBLE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- JH6760000
- CHEMICAL NAME :
- 1,3-Dioxolane
- CAS REGISTRY NUMBER :
- 646-06-0
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C3-H6-O2
- MOLECULAR WEIGHT :
- 74.09
- WISWESSER LINE NOTATION :
- T5O COTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20650 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - renal function tests depressed
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10500 mg/m3/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 32000 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 8480 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1360 mg/m3/4H/22W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased Blood - other changes
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3000 ppm/6H/13W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Endocrine - changes in spleen weight Blood - changes in leukocyte (WBC) count
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1360 mg/m3/4H/22W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased Blood - other changes
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 105000 mg/m3/50D-I
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS
MUTATION DATA
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 290 mg/kg
- REFERENCE :
- STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 107,205,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-HUNGARY:TWA 10 mg/m3;STEL 20 mg/m3;Skin;Carcinogen JAN 1993 OEL-RUSSIA:STEL 50 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84001 No. of Facilities: 256 (estimated) No. of Industries: 13 No. of Occupations: 23 No. of Employees: 10612 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84001 No. of Facilities: 5264 (estimated) No. of Industries: 86 No. of Occupations: 44 No. of Employees: 74949 (estimated) No. of Female Employees: 747 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H319
[ Precautionary Statements ]:
P210-P305 + P351 + P338-P370 + P378-P403 + P235
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US)
[ Hazard Codes ]:
F:Flammable;
[ Risk Phrases ]:
R11
[ Safety Phrases ]:
S16
[ RIDADR ]:
UN 1166 3/PG 2
[ WGK Germany ]:
1
[ RTECS ]:
JH6760000
[ Packaging Group ]:
II
[ Hazard Class ]:
3
[ HS Code ]:
29329970
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 29329970
Articles
ACS Nano 9 , 6147-57, (2015)
This study reports on a facile approach to the fabrication of nanoporous carbon cathodes for lithium sulfur batteries using gyroid carbon replicas based on use of polystyrene-poly-4-vinylpyridine (PS-...
Synthesis of three-dimensionally interconnected sulfur-rich polymers for cathode materials of high-rate lithium-sulfur batteries.Nat. Commun. 6 , 7278, (2015)
Elemental sulfur is one of the most attractive cathode active materials in lithium batteries because of its high theoretical specific capacity. Despite the positive aspect, lithium-sulfur batteries ha...
Reactivity of fullerene epoxide: preparation of fullerene-fused thiirane, tetrahydrothiazolidin-2-one, and 1,3-dioxolane.J. Org. Chem. 73(7) , 2518-26, (2008)
The epoxide moiety in the fullerene-mixed peroxide C60(O)(OOtBu)4 1 reacts readily with aryl isocyanates ArNCS (Ar = Ph, Naph) to form both the thiirane derivative C60(S)(OOtBu)4 and fullerene-fused t...