1,10-Phenanthroline

Names

[ CAS No. ]:
66-71-7

[ Name ]:
1,10-Phenanthroline

[Synonym ]:
1,10-Phenanthroline
4,5-Diazaphenanthrene
4,5-Phenanthroline
ORTHOPHENANTHROLINE
EINECS 200-629-2
1,10-o-Phenanthroline
o-Phenanthroline
β-Phenanthroline
1,10-Fenanthroline
phenanthroline
MFCD00011678
1,10-Fenanthrolin
phen
10-Phenanthroline
T B666 CN NNJ

Biological Activity

[Description]:

o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Guan NanMu, et al. Synergistic inhibition between o-phenanthroline and chloride ion on cold rolled steel corrosion in phosphoric acid. Materials Chemistry and Physics Volume 86, Issue 1, 15 July 2004, Pages 59-68.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
365.1±15.0 °C at 760 mmHg

[ Melting Point ]:
114-117 °C(lit.)

[ Molecular Formula ]:
C₁₂H₈N₂

[ Molecular Weight ]:
180.205

[ Flash Point ]:
164.8±11.7 °C

[ Exact Mass ]:
180.068741

[ PSA ]:
25.78000

[ LogP ]:
1.78

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.740

[ Storage condition ]:
Refrigerator

[ Stability ]:
Stable. Hygroscopic. Store under nitrogen. Incompatible with strong acids, strong oxidizing agents.

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SF8300000

CHEMICAL NAME :: 1,10-Phenanthroline

CAS REGISTRY NUMBER :: 66-71-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C12-H8-N2

MOLECULAR WEIGHT :: 180.22

WISWESSER LINE NOTATION :: T B666 CN NNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 30 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Leukocyte

DOSE/DURATION :: 5 mg/L

REFERENCE :: ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 46,193,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82276 No. of Facilities: 1002 (estimated) No. of Industries: 12 No. of Occupations: 11 No. of Employees: 8324 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82276 No. of Facilities: 2265 (estimated) No. of Industries: 33 No. of Occupations: 35 No. of Employees: 40330 (estimated) No. of Female Employees: 2577 (estimated)

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H410

[ Precautionary Statements ]:
P273-P301 + P310-P501

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R50/53

[ Safety Phrases ]:
S45-S60-S61

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
SF8437000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29339990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

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