NH2-C4-NH-Boc

Names

[ Name ]:
NH2-C4-NH-Boc

[Synonym ]:
2-Methyl-2-propanyl (4-aminobutyl)carbamate
BOC-NH(CH2)4NH2 HCL
tert-butyl 4-aminobutylcarbamate
Carbamic acid, N-(4-aminobutyl)-, 1,1-dimethylethyl ester
(4-amino-butyl)-carbamic acid tert-butyl ester
N-(1,1-dimethylethoxycarbonyl)-1,4-butanediamine
BOC-DIAMINOBUTANE HCL
N-Boc-1,4-butanediamine
N-Boc-1,4-butandiamine
N-T-BOC-BUTANDIAMINE HCL
(4-aminobutyl)carbamic acid 1,1-dimethylethyl ester
BUTTPARK 121 6-09
RARECHEM AR PA 0023
tert-ButylN-(4-aminobutyl)carbamate
4-(t-butoxycarbonylamino)butylamine
N-BOC-1,4-DIAMINOBUTANE
AURORA KA-4397
N-(tert-butoxycarbonyl)-1,4-diamino-butane
BOC-DAB HCL
N-tert-Butoxycarbonyl-1,4-butanediamine
MFCD02090802
tert-butyl 4-amino butylcarbamate

Biological Activity

[Description]:

NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[References]

[1]. Jiang F, et al.Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
292.9±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₂₀N₂O₂

[ Molecular Weight ]:
188.267

[ Flash Point ]:
130.9±22.6 °C

[ Exact Mass ]:
188.152481

[ PSA ]:
64.35000

[ LogP ]:
1.06

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.457

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2735 8/PG 3

[ WGK Germany ]:
3

[ Hazard Class ]:
8.0

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Peptide splicing in a double-sequence analogue of trypsin inhibitor SFTI-1 substituted in the P₁ positions by peptoid monomers.

Biopolymers 104 , 206-12, (2015)

Recently, we described a process of trypsin-assisted peptide splicing of analogs of trypsin inhibitor SFTI-1, that seems to be very similar to proteasome-catalyzed peptide splicing. Here, we show, for...

Synthesis, tubulin binding, antineoplastic evaluation, and structure-activity relationship of oncodazole analogues.

J. Med. Chem. 32 , 409, (1989)

In an attempt to identify a soluble oncodazole analogue that could be easily formulated, a series of substituted oncodazoles was synthesized and evaluated for tubulin binding affinity, in vitro cytoto...

Synthesis and biological evaluation of new citrate-based siderophores as potential probes for the mechanism of iron uptake in mycobacteria.

J. Med. Chem. 45 , 2056, (2002)

Several iron chelators containing alpha,beta-unsaturated hydroxamic acid motifs appended to a citric acid platform were synthesized. Mycobacterium paratuberculosis was then challenged to grow in the p...

Related Compounds

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