SPDP

Names

[ Name ]:
SPDP

[Synonym ]:
MFCD00009636
1-{[3-(2-Pyridinyldisulfanyl)propanoyl]oxy}-2,5-pyrrolidinedione
EINECS 269-034-3
N-succinimidyl 3-(2-pyridyldithio)-propionate
(2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate
1-{[3-(Pyridin-2-yldisulfanyl)propanoyl]oxy}pyrrolidine-2,5-dione
2,5-Pyrrolidinedione, 1-[1-oxo-3-(2-pyridinyldithio)propoxy]-
1-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2,5-dione
2,5-Pyrrolidinedione, 1-(1-oxo-3-(2-pyridinyldithio)propoxy)-
SPDP

Biological Activity

[Description]:

SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[References]

[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7.

[2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
465.9±55.0 °C at 760 mmHg

[ Melting Point ]:
84-86 °C(lit.)

[ Molecular Formula ]:
C₁₂H₁₂N₂O₄S₂

[ Molecular Weight ]:
312.365

[ Flash Point ]:
235.6±31.5 °C

[ Exact Mass ]:
312.023834

[ PSA ]:
127.17000

[ LogP ]:
0.99

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.650

[ Storage condition ]:
−20°C

[ Water Solubility ]:
acetone: 50 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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Related Compounds

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