cytosine
Names
[ CAS No. ]:
71-30-7
[ Name ]:
cytosine
[Synonym ]:
MFCD00006034
Cytosin
EINECS 200-749-5
Cytosinimine
Cytosine
4-aminopyrimidin-2-one
Cyt
Lamivudine Impurity 5
6-Aminopyrimidin-2(1H)-one
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Human Endogenous Metabolite
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
445.8ºC at 760 mmHg
[ Melting Point ]:
>300 °C(lit.)
[ Molecular Formula ]:
C4H5N3O
[ Molecular Weight ]:
111.102
[ Flash Point ]:
223.4ºC
[ Exact Mass ]:
111.043259
[ PSA ]:
71.77000
[ LogP ]:
-2.29
[ Index of Refraction ]:
1.689
[ Storage condition ]:
Store at RT.
[ Stability ]:
Stable. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UW7350150
- CHEMICAL NAME :
- 2(1H)-Pyrimidinone, 4-amino-
- CAS REGISTRY NUMBER :
- 71-30-7
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C4-H5-N3-O
- MOLECULAR WEIGHT :
- 111.12
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2222 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 207,504,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3859 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 312 (estimated) No. of Female Employees: 303 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
UW7350150
[ HS Code ]:
2933599090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933591000
[ Summary ]:
HS:2933591000 4-aminopyrimidin-2(1h)-one VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
Articles
J. Bacteriol. 197(5) , 819-32, (2015)
Clostridium difficile is an anaerobic Gram-positive bacterium that causes intestinal infections with symptoms ranging from mild diarrhea to fulminant colitis. Cyclic diguanosine monophosphate (c-di-GM...
Dynamic switching of active promoter and enhancer domains regulates Tet1 and Tet2 expression during cell state transitions between pluripotency and differentiation.Mol. Cell. Biol. 35(6) , 1026-42, (2015)
The Tet 5-methylcytosine dioxygenases catalyze DNA demethylation by producing 5-hydroxymethylcytosine and further oxidized products. Tet1 and Tet2 are highly expressed in mouse pluripotent cells and d...
ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion.Cell Death Differ. 22 , 1970-84, (2015)
Trophoblasts, placental cells of epithelial lineage, undergo extensive differentiation to form the cellular components of the placenta. Trophoblast progenitor cell differentiation into the multinuclea...