Leukotriene D4

Names

[ Name ]:
Leukotriene D4

[Synonym ]:
(5S,6R,7E,9E,11Z,14Z)-6-({(2R,3Z)-2-Amino-3-[(carboxymethyl)imino]-3-hydroxypropyl}sulfanyl)-5-hydroxy-7,9,11,14-icosatetraenoic acid
Glycine, S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteinyl-
Leukotriene D4
LTD4
S-[(4S,5R,6E,8E,10Z,13Z)-1-Carboxy-4-hydroxy-6,8,10,13-nonadecatetraen-5-yl]-L-cysteinylglycine
7,9,11,14-Eicosatetraenoic acid, 6-[[(2R,3Z)-2-amino-3-[(carboxymethyl)imino]-3-hydroxypropyl]thio]-5-hydroxy-, (5S,6R,7E,9E,11Z,14Z)-
leukotriened

Biological Activity

[Description]:

Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
748.3±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₄₀N₂O₆S

[ Molecular Weight ]:
496.660

[ Flash Point ]:
406.4±35.7 °C

[ Exact Mass ]:
496.260712

[ PSA ]:
175.25000

[ LogP ]:
5.78

[ Vapour Pressure ]:
0.0±5.7 mmHg at 25°C

[ Index of Refraction ]:
1.538

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB9143000

CHEMICAL NAME :: Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecat etraenyl)-L-cysteinyl )-, (R- (R*,S*-(E,E,Z,Z)))-

CAS REGISTRY NUMBER :: 73836-78-9

LAST UPDATED :: 199206

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C25-H40-N2-O6-S

MOLECULAR WEIGHT :: 496.73

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 10 nmol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 51,5573,1991

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310 + P330-P302 + P352 + P312-P370 + P378

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F: Flammable;T: Toxic;

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
7-16-36/37-45

[ RIDADR ]:
UN 1230 3/PG 2

Articles

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.

Nat. Neurosci. 18(1) , 145-53, (2015)

The primary sensory system requires the integrated function of multiple cell types, although its full complexity remains unclear. We used comprehensive transcriptome analysis of 622 single mouse neuro...

Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor.

J. Immunol. 191(12) , 5807-10, (2013)

Leukotriene C4 (LTC4) and its extracellular metabolites, LTD4 and LTE4, mediate airway inflammation. They signal through three specific receptors (type 1 cys-LT receptor [CysLT1R], CysLT2R, and GPR99)...

A contraction assay system using primary cultured mouse bronchial smooth muscle cells.

Int. Arch. Allergy Immunol. 161 Suppl 2 , 93-7, (2013)

Contraction of bronchial smooth muscle is the main mechanism of asthmatic responses. Inflammatory cells such as eosinophils and mast cells produce chemical mediators that induce smooth muscle contract...

Related Compounds

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