4-Amidinophenylmethanesulfonyl fluoride hydrochloride

Names

[ Name ]:
4-Amidinophenylmethanesulfonyl fluoride hydrochloride

[Synonym ]:
(4-Carbamimidoylphenyl)methanesulfonyl fluoride hydrochloride
(4-Carbamimidoylphenyl)methanesulfonyl fluoride hydrochloride (1:1)
Benzenemethanesulfonyl fluoride, 4-(aminoiminomethyl)-, hydrochloride (1:1)
(4-carbamimidoylphenyl)methanesulfonyl fluoride,hydrochloride
MFCD00036898

Biological Activity

[Description]:

p-APMSF is an irreversible inhibitor of serinase. p-APMSFhas substrate specificity for positively charged side chains of amino acids,lysine, or arginine. p-APMSF can be used to study the irreversible inhibitionof trypsin and thrombin [1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. LauraR, et al. (p-Amidinophenyl)methanesulfonyl fluoride, an irreversible inhibitorof serine proteases. Biochemistry. 1980 Oct 14;19(21):4859-64.

Chemical & Physical Properties

[ Boiling Point ]:
405.2ºC at 760 mmHg

[ Melting Point ]:
~205 °C (dec.)

[ Molecular Formula ]:
C₈H₁₀ClFN₂O₂S

[ Molecular Weight ]:
252.69

[ Flash Point ]:
198.8ºC

[ Exact Mass ]:
252.013550

[ PSA ]:
92.39000

[ LogP ]:
3.45280

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 50 mM Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22-36/37/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2925290090

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

In vivo pharmacological characterization of TAK-063, a potent and selective phosphodiesterase 10A inhibitor with antipsychotic-like activity in rodents.

J. Pharmacol. Exp. Ther. 352(3) , 471-9, (2015)

Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP phosphodiesterase highly expressed in medium spiny neurons (MSNs) in the striatum. We evaluated the in vivo pharmacological profile of a potent and select...

Zinc binding activity of human metapneumovirus M2-1 protein is indispensable for viral replication and pathogenesis in vivo.

J. Virol. 89 , 6391-405, (2015)

Human metapneumovirus (hMPV) is a member of the Pneumovirinae subfamily in the Paramyxoviridae family that causes respiratory tract infections in humans. Unlike members of the Paramyxovirinae subfamil...

APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription.

FEBS Lett. 589(4) , 532-9, (2015)

APPL1 is a multifunctional endocytic adaptor which acts at different steps of various signaling pathways. Here we report that APPL1 interacts with Dvl2, a protein known to activate the canonical and n...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.