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isopropylamine

Names

[ CAS No. ]:
75-31-0

[ Name ]:
isopropylamine

[Synonym ]:
Dimethylmethaneamine
1-Methylethylamine
2-Propanamine
Isopropylamine
2-Aminopropane
MFCD00008082
2-Amino-propaan
propan-2-amine
Propane, 2-amino-
isopropyl amine
2-Propylamine
2-AMINO-PROPANE
sec-Propylamine
EINECS 200-860-9
Propane,2-amino
MONOISOPROPYLAMINE

Chemical & Physical Properties

[ Density]:
0.7±0.1 g/cm3

[ Boiling Point ]:
30.9±8.0 °C at 760 mmHg

[ Melting Point ]:
-101 °C

[ Molecular Formula ]:
C3H9N

[ Molecular Weight ]:
59.110

[ Flash Point ]:
-32.2±0.0 °C

[ Exact Mass ]:
59.073498

[ PSA ]:
26.02000

[ LogP ]:
0.21

[ Vapour density ]:
2.04 (vs air)

[ Vapour Pressure ]:
607.7±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.389

[ Stability ]:
Stable. Extremely flammable - note low boiling point and low flash point. Readily forms explosive mixtures with air. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, perchloryl fluoride.

[ Water Solubility ]:
soluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NT8400000
CHEMICAL NAME :
Isopropylamine
CAS REGISTRY NUMBER :
75-31-0
LAST UPDATED :
199806
DATA ITEMS CITED :
36
MOLECULAR FORMULA :
C3-H9-N
MOLECULAR WEIGHT :
59.13
WISWESSER LINE NOTATION :
ZY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/15/1971
TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
820 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 11/15/1971
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4000 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974 Volume(issue)/page/year: 17JUN1974
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 31,238,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(3),79,1980
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7000 ppm/40M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,7,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3200 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(3),79,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974 Volume(issue)/page/year: 17JUN1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(3),79,1980
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
1800 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 14,80,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 14,80,1975 *** REVIEWS *** ACGIH TLV-STEL 24 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 12 mg/m3 (5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (12 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,141,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (12 mg/m3);STEL 10 ppm (24 mg/m3) JAN 1993 OEL-BELGIUM:TWA 5 ppm (12 mg/m3);STEL 10 ppm (24 mg/m3) JAN 1993 OEL-DENMARK:TWA 5 ppm (12 mg/m3) JAN 1993 OEL-FRANCE:TWA 5 ppm (12 mg/m3) JAN 1993 OEL-GERMANY:TWA 5 ppm (12 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (12 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (12 mg/m3) JAN 1993 OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (12 mg/m3);STEL 10 ppm (24 mg/m3) JAN 1993 OEL-TURKEY:TWA 5 ppm (12 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 40990 No. of Facilities: 808 (estimated) No. of Industries: 10 No. of Occupations: 14 No. of Employees: 13196 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 40990 No. of Facilities: 235 (estimated) No. of Industries: 6 No. of Occupations: 7 No. of Employees: 8134 (estimated) No. of Female Employees: 3174 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H224-H301 + H311 + H331-H314-H335

[ Precautionary Statements ]:
P210-P261-P280-P303 + P361 + P353-P305 + P351 + P338-P370 + P378

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R12;R36/37/38

[ Safety Phrases ]:
S16-S26-S29

[ RIDADR ]:
UN 1221 3/PG 1

[ WGK Germany ]:
1

[ RTECS ]:
NT8400000

[ Packaging Group ]:
I

[ Hazard Class ]:
3

Synthetic Route

Precursor & DownStream

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