HEPES sodium salt

Names

[ Name ]:
HEPES sodium salt

[Synonym ]:
1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1)
HEPES sodium salt
EINECS 278-169-7
Sodium 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonate
MFCD00036463
1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt

Biological Activity

[Description]:

HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

HEPES maintains superhydrophilicity of titanium for at least 3 months and resulted in a continuous retention of bioactivity and osteoconductivity[1]. HEPES drives lysosome biogenesis, affects MiT/TFE cytoplasmic-nuclear distribution, disrupts global cellular transcriptional profiles, resulting the activation of a MiT/TFE-dependent lysosomal-autophagic gene network in cultured RAW264.7 cells[3].

[References]

[1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828.

[2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492.

[3]. https://pubmed.ncbi.nlm.nih.gov/20631430/

Chemical & Physical Properties

[ Melting Point ]:
234ºC

[ Molecular Formula ]:
C₈H₁₇N₂NaO₄S

[ Molecular Weight ]:
260.286

[ Exact Mass ]:
260.080658

[ PSA ]:
92.29000

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Hygroscopic - protect from moisture. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
H2O: 1 M at 20 °C, clear, colorless

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29335995

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

[Permeability of pannexin 1 channels to large anions].

Ross. Fiziol. Zh. Im. I. M. Sechenova 98(12) , 1578-86, (2012)

It is widely accepted that ATP secretion in diverse cells involves pannexin 1 (Panx1) that functions as an ATP-permeable channel. We analyzed the permeability of Panx1 channels heterologically express...

Factor VIII organisation on nanodiscs with different lipid composition.

Thromb. Haemost. 113(4) , 741-9, (2015)

Nanodiscs (ND) are lipid bilayer membrane patches held by amphiphilic scaffolding proteins (MSP) of ~10 nm in diameter. Nanodiscs have been developed as lipid nanoplatforms for structural and function...

Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2.

Toxicol. Appl. Pharmacol. 289 , 223-30, (2015)

Combustion processes generate different types of particulate matter (PM) that can have deleterious effects on the pulmonary and cardiovascular systems. Environmentally persistent free radicals (EPFRs)...

Related Compounds

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