Diazald
Names
[ CAS No. ]:
80-11-5
[ Name ]:
Diazald
[Synonym ]:
N,4-Dimethyl-N-nitrosobenzenesulfonamide
MFCD00002050
N-methyl-N-nitrosotoluene-p-sulfonamide
Benzenesulfonic acid, 4-methyl-, 1-methyl-2-oxohydrazide
EINECS 201-252-6
N-Methyl-N-nitroso-p-toluenesulfonamide
Diazald
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
320.5±35.0 °C at 760 mmHg
[ Melting Point ]:
~58 °C
[ Molecular Formula ]:
C8H10N2O3S
[ Molecular Weight ]:
214.242
[ Flash Point ]:
147.6±25.9 °C
[ Exact Mass ]:
214.041214
[ PSA ]:
75.19000
[ LogP ]:
0.58
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.573
[ Storage condition ]:
2-8°C
[ Stability ]:
Stable, but heat sensitive; may also be light sensitive. Incompatible with strong oxidizing agents, alkalies.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XT5950000
- CHEMICAL NAME :
- p-Toluenesulfonamide, N-methyl-N-nitroso-
- CAS REGISTRY NUMBER :
- 80-11-5
- BEILSTEIN REFERENCE NO. :
- 2214345
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C8-H10-N2-O3-S
- MOLECULAR WEIGHT :
- 214.26
- WISWESSER LINE NOTATION :
- ONN1&SWR D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 19 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease
- TYPE OF TEST :
- Specific locus test
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,11,1981
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H242-H315-H317-H319-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
E:Explosive;Xi:Irritant;
[ Risk Phrases ]:
R2;R36/37/38;R43
[ Safety Phrases ]:
S15-S26-S35-S36/37
[ RIDADR ]:
UN 3234 4.1/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
XT5950000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2935009090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2935009090
[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
Articles
Appl. Environ. Microbiol. 80(24) , 7592-603, (2014)
The betaproteobacteria "Aromatoleum aromaticum" pCyN1 and "Thauera" sp. strain pCyN2 anaerobically degrade the plant-derived aromatic hydrocarbon p-cymene (4-isopropyltoluene) under nitrate-reducing c...
Diazald, a newly recognized antimicrobial agent and its spectrophotometric determination.Acta Microbiol. Hung. 39(3-4) , 317-22, (1992)
Diazald, a chemical intermediate for the synthesis of biologically active compounds, was found to be a potent in vitro antimicrobial agent against yeasts, yeast-like and filamentous fungi as well as G...
Transnitrosating activity of N-nitroso-N-methyl-p-toluenesulfonamide in rats and human gastric juice.Neoplasma 35(3) , 257-62, (1988)
N-nitroso-N-methyl-p-toluenesulfonamide (NMTS, diazald, CAS 80-11-5) is a widely used compound for laboratory production of diazomethane. The present results showed that the noncarcinogenic NMTS react...