1,2-Distearoyl-sn-glycero-3-phosphocholine

Names

[ CAS No. ]:
816-94-4

[ Name ]:
1,2-Distearoyl-sn-glycero-3-phosphocholine

[Synonym ]:
EINECS 212-440-2
MFCD00036905
(2R)-2,3-Bis(stearoyloxy)propyl 2-(trimethylammonio)ethyl phosphate
1,2-Distearoyl-sn-glycero-3-phosphocholine
Ethanaminium, 2-[[[(2R)-2,3-bis[(1-oxooctadecyl)oxy]propoxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt
(2R)-2,3-bis(octadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate
L-α-PHOSPHATIDYLCHOLINE, DISTEAROYL

Biological Activity

[Description]:

1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

In empty lipid nanoparticle (LNP) systems that do not contain siRNA, DSPC-cholesterol resides in outer layers, whereas in loaded systems a portion of the DSPC-cholesterol is internalised together with siRNA[2].

[References]

[1]. Andrew D Miller. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811.

[2]. Jayesh A Kulkarni, et al. On the role of helper lipids in lipid nanoparticle formulations of siRNA. Nanoscale. 2019 Nov 21;11(45):21733-21739.

Chemical & Physical Properties

[ Melting Point ]:
236 °C

[ Molecular Formula ]:
C₄₄H₈₈NO₈P

[ Molecular Weight ]:
790.145

[ Exact Mass ]:
789.624756

[ PSA ]:
121.00000

[ LogP ]:
13.00

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Immunoliposomes containing Soluble Leishmania Antigens (SLA) as a novel antigen delivery system in murine model of leishmaniasis.

Exp. Parasitol. 146 , 78-86, (2014)

Development of new generation of vaccines against leishmaniasis requires adjuvants to elicit the type and intensity of immune response needed for protection. The coupling of target-specific antibodies...

Defective functionality of HDL particles in familial apoA-I deficiency: relevance of alterations in HDL lipidome and proteome.

J. Lipid Res. 55(12) , 2509-20, (2014)

To evaluate functional and compositional properties of HDL in subjects from a kindred of genetic apoA-I deficiency, two homozygotes and six heterozygotes, with a nonsense mutation at APOA1 codon -2, Q...

Ultrasound triggered drug delivery with liposomal nested microbubbles.

Ultrasonics 63 , 31-8, (2015)

When ultrasound contrast agent microbubbles are nested within a liposome, damage to the liposome membrane caused by both stable and inertial cavitation of the microbubble allows for release of the aqu...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.