dl-methionine sulfone

Names

[ CAS No. ]:
820-10-0

[ Name ]:
dl-methionine sulfone

[Synonym ]:
methionine S,S-dioxide
DL-LOBAMINE SULFONE
METHIONINESULPHONE
DL-METHIONINE SULFONE
DL-BANTHIONINE SULFONE
EINECS 212-466-4
Butanoic acid, 2-amino-4-(methylsulfonyl)-
methionine sulfoxide
2-Amino-4-(methylsulfonyl)butanoic acid
Methionine sulfone
MFCD00025079
DL-methionine S-dioxide
UNII:5503K54L0R

Biological Activity

[Description]:

DL-Methionine Sulfone is a Methionine (HY-13694) derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
450.5±40.0 °C at 760 mmHg

[ Melting Point ]:
250ºC

[ Molecular Formula ]:
C₅H₁₁NO₄S

[ Molecular Weight ]:
181.210

[ Flash Point ]:
226.3±27.3 °C

[ Exact Mass ]:
181.040878

[ PSA ]:
105.84000

[ LogP ]:
-1.27

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.512

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

In Salmonella enterica, the Gcn5-related acetyltransferase MddA (formerly YncA) acetylates methionine sulfoximine and methionine sulfone, blocking their toxic effects.

J. Bacteriol. 197(2) , 314-25, (2015)

Protein and small-molecule acylation reactions are widespread in nature. Many of the enzymes catalyzing acylation reactions belong to the Gcn5-related N-acetyltransferase (GNAT; PF00583) family, named...

Copper(II) complexes of neurokinin A with point mutation (S5A) and products of copper-catalyzed oxidation; role of serine residue in peptides containing neurokinin A sequence.

J. Inorg. Biochem. 121 , 1-9, (2013)

A potentiometric, spectroscopic (UV-visible, CD and EPR) and electrospray ionization mass spectrometric (ESI-MS) study of Cu(II) binding to the neurokinin A with point mutation (S5A) (ANKA), His-Lys-T...

Analysis of methionine oxides and nitrogen-transporting amino acids in chilled and acclimated maize seedlings.

Amino Acids 33(4) , 607-13, (2007)

In maize seedlings, chilling causes a reduction of glutamine synthetase (GS) activity, while acclimation protects GS (manuscript submitted). Since ROS can oxidize both protein-bound and free Met to me...

Related Compounds

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