Carbazole

Names

[ CAS No. ]:
86-74-8

[ Name ]:
Carbazole

[Synonym ]:
diphenylenimine
DIPHENYLIMIDE
Carbazole
polycarbazole
2-(2-Bromoanilino)pyridine
Diphenylimid
9H-CARBAZOLE
Dibenzopyrrol
EINECS 201-696-0
'LGC' (2409)
usafek-600
dibenzopyrrole
9-AZAFLUORENE
MFCD00004960

Biological Activity

[Description]:

Carbazole is a tricyclic aromatic heterocyclic. Carbazole can form a new type of DNA minor groove complex to suppress the synthesis of new DNA or RNA[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Research Areas >> Others

[References]

[1]. F A Tanious, et al. A new type of DNA minor-groove complex: carbazole dication-DNA interactions. Biochemistry. 1997 Dec 9;36(49):15315-25.

[2]. carbazole and its derivatives as antitumor agents. Anticancer Agents Med Chem. 2015;15(8):1049-65.

[3]. Kai Lin Woon, et al. Effect of conjugation and aromaticity of 3,6 di-substituted carbazoles on triplet energy and the implication of triplet energy in multiple-cyclic aromatic compounds. RSC Adv., 2018, 8, 9850-9857.

Chemical & Physical Properties

[ Density]:
1.1

[ Boiling Point ]:
355.0±11.0 °C at 760 mmHg

[ Melting Point ]:
243-246 °C(lit.)

[ Molecular Formula ]:
C₁₂H₉N

[ Molecular Weight ]:
167.207

[ Flash Point ]:
220 ºC

[ Exact Mass ]:
167.073502

[ PSA ]:
15.79000

[ LogP ]:
3.72

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.768

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, nitrogen oxides, potassium hydroxide.

[ Water Solubility ]:
<0.1 g/100 mL at 19 ºC

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351-H413

[ Precautionary Statements ]:
P281

[ Target Organs ]:
Blood, Central nervous system, Liver

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R40;R50/53

[ Safety Phrases ]:
S26-S36-S60-S61-S36/37-S24/25-S23-S53

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
FE3150000

[ Packaging Group ]:
III

[ Hazard Class ]:
9

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Electromechanical response of silk fibroin hydrogel and conductive polycarbazole/silk fibroin hydrogel composites as actuator material.

Mater. Sci. Eng. C. Mater. Biol. Appl. 56 , 1-8, (2015)

Pure silk fibroin (SF) hydrogel and polycarbazole/silk fibroin (SF/PCZ) hydrogels were fabricated by solvent casting technique to evaluate electromechanical responses, dielectric properties, and canti...

Clausenawallines G-K, carbazole alkaloids from Clausena wallichii twigs.

Phytochemistry 88 , 74-8, (2013)

Five carbazole alkaloids, clausenawallines G-K (1-5), along with 12 known alkaloids (6-17) were isolated from the twigs of Clausena wallichii. Their structures were established using spectroscopic met...

Related Compounds

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