Neurokinin B trifluoroacetate salt

Names

[ Name ]:
Neurokinin B trifluoroacetate salt

[Synonym ]:
Neurokinin B NKB
DMHDFFVGLM-NH2
NKB
NEUROKININ K
MFCD00133665
NEUROKININ B
NEUROMEDIN K

Biological Activity

[Description]:

Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs—including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Peptides

[Target]

Neurokinin receptor[1]

[In Vitro]

Neurokinin B (NKB) belongs to the tachykinin family of peptides that initially included the neuropeptides substance P (SP), neurokinin A (NKA), and NKB and more recently, endokinins and hemokinins. Tachykinins bind a family of G-protein-coupled receptors (GPCRs)-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect[1].

[References]

[1]. Navarro VM. Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol. 2013;784:325-47.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.313 g/cm3

[ Boiling Point ]:
1646ºC at 760 mmHg

[ Molecular Formula ]:
C₅₅H₇₉N₁₃O₁₄S₂

[ Molecular Weight ]:
1210.42000

[ Flash Point ]:
949.3ºC

[ Exact Mass ]:
1209.53000

[ PSA ]:
484.89000

[ LogP ]:
3.32120

[ Index of Refraction ]:
1.591

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Current and future applications of GnRH, kisspeptin and neurokinin B analogues.

Nat. Rev. Endocrinol. 9(8) , 451-66, (2013)

Reproductive hormones affect all stages of life from gamete production, fertilization, fetal development and parturition, neonatal development and puberty through to adulthood and senescence. The repr...

Neuroanatomy of the kisspeptin signaling system in mammals: comparative and developmental aspects.

Adv. Exp. Med. Biol. 784 , 27-62, (2013)

Our understanding of kisspeptin and its actions depends, in part, on a detailed knowledge of the neuroanatomy of the kisspeptin signaling system in the brain. In this chapter, we will review our curre...

Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function.

J. Neurosci. 32(33) , 11486-94, (2012)

It is increasingly accepted that alterations of the early life environment may have lasting impacts on physiological functions. In particular, epidemiological and animal studies have indicated that ch...

Related Compounds

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