Resorufin pentyl ether

Names

[ Name ]:
Resorufin pentyl ether

[Synonym ]:
7-pentoxyphenoxazin-3-one
PENTOXYRESORUFIN
O-Pentylresorufin
7-PENTOXYRESORUFIN
7-PENTYLOXY-3-PHENOXAZONE
7-amoxyphenoxazin-3-one
7-Pentoxyphenoxazone
7-Pentoxy-3H-phenoxazin-3-one
O(7)-PENTYLRESORUFIN

Biological Activity

[Description]:

Resorufin pentyl ether (Pentoxyresorufin; 7-Pentoxyphenoxazone) is a Resazurin (HY-111391) analogue. Resorufin pentyl ether acts as a substrate to distinguish between different induced cytochromes P-450. Resorufin pentyl ether maintains bactericidal activity against N. gonorrhoeae in vitro[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Deanna M. Schmitt, et al. Antibacterial activity of resazurin-based compounds against Neisseria gonorrhoeae in vitro and in vivo. Int J Antimicrob Agents. 2016 Oct; 48(4): 367–372.

[2]. M D Burke, et al. ETHOXY-, PENTOXY- AND BENZYLOXYPHENO~ZONES AND HOMOLOGUES: A SERIES OF SUBSTRATES TO DISTINGUISH BETWEEN DIFFERENT INDUCED CYTOCHROMES P-450. Biochem Pharmacol. 1985 Sep 15;34(18):3337-45.

Chemical & Physical Properties

[ Density]:
1.2g/cm3

[ Boiling Point ]:
423.6ºC at 760 mmHg

[ Melting Point ]:
151-153ºC

[ Molecular Formula ]:
C₁₇H₁₇NO₃

[ Molecular Weight ]:
283.32200

[ Flash Point ]:
183.4ºC

[ Exact Mass ]:
283.12100

[ PSA ]:
52.33000

[ LogP ]:
3.86180

[ Index of Refraction ]:
1.594

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Effect of commercially available green and black tea beverages on drug-metabolizing enzymes and oxidative stress in Wistar rats.

Food Chem. Toxicol. 70 , 120-7, (2014)

The effect of commercially available green tea (GT) and black tea (BT) drinks on drug metabolizing enzymes (DME) and oxidative stress in rats was investigated. Male Wistar rats were fed a laboratory c...

In vivo indirect measurement of cytochrome P450-associated activities in freshwater gastropod molluscs.

Environ. Toxicol. 25(6) , 545-53, (2010)

The cytochrome P450 (CYP) system is widely distributed across phyla and plays a key role in the metabolism of xenobiotic compounds. However, most studies on CYP system were developed on vertebrates an...

Effects of age increase on hepatic expression and activity of cytochrome P450 in male C57BL/6 mice.

Arch. Pharm. Res. 38 , 857-64, (2015)

Effects of aging on hepatic expression and activity of cytochrome P450 (CYP) isoforms were investigated in male mice aged 2, 6, 18, and 30 months. Microsomal protein, total CYP, cytochrome b5 and NADP...

Related Compounds

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