Clofibric acid
Names
[ CAS No. ]:
882-09-7
[ Name ]:
Clofibric acid
[Synonym ]:
Clofibrin
Regulipid
a-(p-Chlorophenoxy)isobutyric Acid
2-(p-chlorophenoxy)-isobutyric acid
PCIB
4-CPIB
2-(4-Chlorophenoxy)-2-methylpropanoic acid
Clofibric
2-(4-chlorophenoxy)isobutyric acid
Chlorofibrinic acid
Arteriohom
PCPIB
Clofibric acid
Chlorfibrinic acid
EINECS 212-925-9
Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-
MFCD00004192
4-Chlorophenoxy-iso-butyric Acid
2-(p-Chlorophenoxy)-2-methylpropionic Acid
2-(4-Chlorophenoxy)-2-methylpropionic acid
Clofibric acid [DCF:INN]
Clofibrinic acid
Regadrin
Biological Activity
[Description]:
[Related Catalog]:
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
324.1±17.0 °C at 760 mmHg
[ Melting Point ]:
120-122 °C(lit.)
[ Molecular Formula ]:
C10H11ClO3
[ Molecular Weight ]:
214.645
[ Flash Point ]:
149.8±20.9 °C
[ Exact Mass ]:
214.039673
[ PSA ]:
46.53000
[ LogP ]:
2.72
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.541
[ Storage condition ]:
Store at RT
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UE9455000
- CHEMICAL NAME :
- Propionic acid, 2-(p-chlorophenoxy)-2-methyl-
- CAS REGISTRY NUMBER :
- 882-09-7
- BEILSTEIN REFERENCE NO. :
- 1874067
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C10-H11-Cl-O3
- MOLECULAR WEIGHT :
- 214.66
- WISWESSER LINE NOTATION :
- QVX1&1&OR DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 260 mg/kg/91D
- TOXIC EFFECTS :
- Liver - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 897 mg/kg
- TOXIC EFFECTS :
- Liver - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 727 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1170 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 290 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 683 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 219 gm/kg/2Y-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Metabolism (Intermediary) - lipids including transport
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 17750 mg/kg/10W-C
- TOXIC EFFECTS :
- Liver - other changes Liver - changes in liver weight Biochemical - Effect on specific coenzyme - CoA
MUTATION DATA
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 2100 mg/kg/1W (Continuous)
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1557,1991
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;Xi: Irritant;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S36-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
UE9455000
[ HS Code ]:
2918990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2918990090
[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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