3′,5′-Cyclic nucleotide phosphodiesterase

[Description]:

[Related Catalog]:

[ Boiling Point ]:
572.9±52.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₈AsNO₅

[ Molecular Weight ]:
261.064

[ Flash Point ]:
253.4±19.1 °C

[ Exact Mass ]:
260.961853

[ LogP ]:
-0.25

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Storage condition ]:
20°C

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
T

[ RIDADR ]:
NONH for all modes of transport

Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis.

Mol. Pharmacol. 84(6) , 787-93, (2013)

Tissue fibrosis is characterized by excessive production, deposition, and contraction of the extracellular matrix (ECM). The second messenger cAMP has antifibrotic effects in fibroblasts from several ...

Regulation of ecto-apyrase CD39 (ENTPD1) expression by phosphodiesterase III (PDE3).

FASEB J. 27(11) , 4419-28, (2013)

The ectoenzyme CD39 suppresses thrombosis and inflammation by suppressing ATP and ADP to AMP. However, mechanisms of CD39 transcriptional and post-translational regulation are not well known. Here we ...

Inhibition of phosphodiesterase-1 attenuates cold-induced pulmonary hypertension.

Hypertension 61(3) , 585-92, (2013)

Chronic exposure to cold caused pulmonary arterial hypertension (cold-induced pulmonary hypertension [CIPH]) and increased phosphodiesterase-1C (PDE-1C) expression in pulmonary arteries (PAs) in rats....

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