leucoline
Names
[ CAS No. ]:
91-22-5
[ Name ]:
leucoline
[Synonym ]:
1-Azanaphthalene
Chinolin
EINECS 202-051-6
1-Benzazine
Quinolin
Chinoline
leucoline
Leucol
β-Quinoline
Quinoline
MFCD00006736
Chinoleine
Benzopyridine
Fasudil Impurity 8
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
234.1±9.0 °C at 760 mmHg
[ Melting Point ]:
−17-−13 °C(lit.)
[ Molecular Formula ]:
C9H7N
[ Molecular Weight ]:
129.159
[ Flash Point ]:
101.1±0.0 °C
[ Exact Mass ]:
129.057846
[ PSA ]:
12.89000
[ LogP ]:
2.08
[ Vapour density ]:
4.5 (vs air)
[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.642
[ Stability ]:
Stable. Incompatible with strong acids, strong oxidizing agents. May discolour on exposure to light. Hygroscopic - protect from moisture. Reacts violently and unpredictably with some materials, especially strong oxidizing agents.
[ Water Solubility ]:
slightly soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VA9275000
- CHEMICAL NAME :
- Quinoline
- CAS REGISTRY NUMBER :
- 91-22-5
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 32
- MOLECULAR FORMULA :
- C9-H7-N
- MOLECULAR WEIGHT :
- 129.17
- WISWESSER LINE NOTATION :
- T66 BNJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 331 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 540 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7770 mg/kg/37W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 gm/kg/30W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9042 ug/kg/15D-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 23 gm/kg/30W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Mutation in mammalian somatic cells
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 110 ug/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,1,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84566 No. of Facilities: 258 (estimated) No. of Industries: 7 No. of Occupations: 7 No. of Employees: 29238 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84566 No. of Facilities: 456 (estimated) No. of Industries: 9 No. of Occupations: 16 No. of Employees: 4241 (estimated) No. of Female Employees: 810 (estimated)
Safety Information
[ Symbol ]:
GHS06, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H312-H315-H319-H341-H350-H411
[ Precautionary Statements ]:
P201-P273-P280-P301 + P310-P305 + P351 + P338-P308 + P313
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R21/22;R37/38;R40;R41;R68
[ Safety Phrases ]:
S26-S36/37/39-S36-S23
[ RIDADR ]:
UN 2656 6.1/PG 3
[ WGK Germany ]:
2
[ RTECS ]:
VA9275000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
2933499090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933499090
[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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