2-Chloroacrylonitrile
Names
[ CAS No. ]:
920-37-6
[ Name ]:
2-Chloroacrylonitrile
[Synonym ]:
2-chloro-acrylonitrile
2-CHLOROCYANOETHYLENE
1-Chloroaerylonitrile
MFCD00001858
2-PROPENONITRLLE
Chloroacrylonitrile
2-Propenenitrile, 2-chloro-
2-chloro-acrylonitril
NCYGU1
2-Chloroacrylonitrile
β-Chloroacrylonitrile
2-CHLORACRYLONITRIL
EINECS 213-055-2
2-Chloroprop-2-enenitrile
1-Cyanovinyl chloride
2-chloroacrylnitrile
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
89.5±13.0 °C at 760 mmHg
[ Melting Point ]:
−65 °C(lit.)
[ Molecular Formula ]:
C3H2ClN
[ Molecular Weight ]:
87.508
[ Flash Point ]:
6.7±0.0 °C
[ Exact Mass ]:
86.987579
[ PSA ]:
23.79000
[ LogP ]:
0.34
[ Vapour Pressure ]:
58.4±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.435
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AT5525000
- CHEMICAL NAME :
- Acrylonitrile, 2-chloro-
- CAS REGISTRY NUMBER :
- 920-37-6
- BEILSTEIN REFERENCE NO. :
- 0773744
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C3-H2-Cl-N
- MOLECULAR WEIGHT :
- 87.51
- WISWESSER LINE NOTATION :
- NCYGU1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Vascular - regional or general arteriolar or venous dilation Skin and Appendages - hair
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555346
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 304 mg/m3/6H
- TOXIC EFFECTS :
- Vascular - regional or general arteriolar or venous dilation Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - hair
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555346
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Vascular - regional or general arteriolar or venous dilation Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555346
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555346
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 105 mg/m3/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 27(2),52,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Skin and Appendages - hair
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555346
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02164
Safety Information
[ Symbol ]:
GHS02, GHS05, GHS06, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H300 + H310 + H330-H314-H334-H350-H400
[ Precautionary Statements ]:
P201-P210-P260-P280-P284-P301 + P310 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P308 + P313-P403 + P233
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F:Flammable
[ Risk Phrases ]:
R11;R23/24;R28;R36/37/38;R40
[ Safety Phrases ]:
S53-S26-S36/37/39-S45-S61-S28A-S16-S1
[ RIDADR ]:
UN 3383 6.1/PG 1
[ WGK Germany ]:
3
[ RTECS ]:
AT5525000
[ Packaging Group ]:
II
[ Hazard Class ]:
3.1
[ HS Code ]:
2926909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2926909090
[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Toxicology 56(1) , 47-61, (1989)
The nephrotoxicity of glutathione (GSH) pathway metabolites derived from toluene (TOL), styrene (STYR), bromobenzene (BB), acrylonitrile (ACLN) and 2-chloroacrylonitrile (CACLN) were compared with tha...
[Information from the Soviet Toxicology Center].Gig. Tr. Prof. Zabol. (2) , 52-3, (1983)
Dual-function cinchona alkaloid catalysis: catalytic asymmetric tandem conjugate addition-protonation for the direct creation of nonadjacent stereocenters.
J. Am. Chem. Soc. 128(12) , 3928-30, (2006)
Catalytic tandem asymmetric reactions constitute a powerful strategy for the asymmetric construction of nonadjacent stereocenters in acyclic molecules directly from achiral precursors. In this Communi...