N-Phenylmaleimide
Names
[ CAS No. ]:
941-69-5
[ Name ]:
N-Phenylmaleimide
[Synonym ]:
N-Phenylmaleimide
N-Phenylmaleimide(N-PMI)
Maleanil
EINECS 213-382-0
phenylmaleimide
1-phenylpyrrole-2,5-dione
MFCD00005502
1-Phenyl-1H-pyrrole-2,5-dione
1-phenyl-2,5-dihydro-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 1-phenyl-
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
299.3±9.0 °C at 760 mmHg
[ Melting Point ]:
85-87 °C(lit.)
[ Molecular Formula ]:
C10H7NO2
[ Molecular Weight ]:
173.168
[ Flash Point ]:
136.8±11.1 °C
[ Exact Mass ]:
173.047684
[ PSA ]:
37.38000
[ LogP ]:
1.09
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.630
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ON5950000
- CHEMICAL NAME :
- Maleimide, N-phenyl-
- CAS REGISTRY NUMBER :
- 941-69-5
- BEILSTEIN REFERENCE NO. :
- 0125098
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C10-H7-N-O2
- MOLECULAR WEIGHT :
- 173.18
- WISWESSER LINE NOTATION :
- T5VNVJ BR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,8,1961 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 188 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,8,1961
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,22,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 78 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,8,1961
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,8,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9528 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 30 (estimated) No. of Female Employees: 20 (estimated)
Safety Information
[ Symbol ]:
GHS05, GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H315-H317-H318-H400
[ Precautionary Statements ]:
P273-P280-P301 + P310-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T:Toxic;
[ Risk Phrases ]:
R25;R36/37/38
[ Safety Phrases ]:
S45-S24/25
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
ON5950000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
2925190090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2925190090
[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Org. Biomol. Chem. 10(31) , 6388-94, (2012)
The combination of methyl 3,7-dioxo-2-diazo-4-octenoate from the zinc triflate catalyzed Mukaiyama-Michael reaction of methyl 3-tert-butylsilyloxy-2-diazobutenoate and 4-methoxy-3-buten-2-one with Mic...
Chemical modification of milk xanthine oxidase with different modifiers.Prep Biochem Biotechnol. 33(3) , 173-87, (2003)
Xanthine oxidase (XO), purified from buttermilk was subjected to modification with N-phenylmaleimide, p-toluene-sulfonyl chloride, and 2-mercaptobenzimidazole. Spectrophotometric monitoring of the enz...
Behavior of N-phenylmaleimide- and p-phenylenedimaleimide-reacted muscle crossbridge heads.Biochim. Biophys. Acta 1367(1-3) , 127-33, (1998)
The finding of Barnett et al. (Biophys. J. 61 (1992) 358) that NPM-reacted crossbridge heads do not bind strongly to actin in rigor solution is not easily interpreted in terms of the solution studies ...