5-hydroxy Thiabendazole

[Description]:

[Related Catalog]:

[References]

[ Density]:
1.535g/cm3

[ Boiling Point ]:
525.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₇N₃OS

[ Molecular Weight ]:
217.25

[ Flash Point ]:
271.7ºC

[ Exact Mass ]:
217.03100

[ PSA ]:
90.04000

[ LogP ]:
2.39200

[ Index of Refraction ]:
1.783

[ Storage condition ]:
0-6°C

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H400

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
22-50/53

[ Safety Phrases ]:
60-61

[ RIDADR ]:
UN 3077

[ Packaging Group ]:
III

[ Hazard Class ]:
9

[ HS Code ]:
2934999090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Multi-residue Determination of Polar Veterinary Drugs in Livestock and Fishery Products by Liquid Chromatography/Tandem Mass Spectrometry.

J. AOAC Int. 98(1) , 230-47, (2015)

Residues of 37 polar veterinary drugs belonging to six families (quinolones, tetracyclines, macrolides, lincosamides, sulfonamides, and others) in livestock and fishery products were determined using ...

Evidence for cytochrome P4501A2-mediated protein covalent binding of thiabendazole and for its passive intestinal transport: use of human and rabbit derived cells.

Chem. Biol. Interact. 127(2) , 109-24, (2000)

Thiabendazole (TBZ), an anthelmintic and fungicide benzimidazole, was recently demonstrated to be extensively metabolized by cytochrome P450 (CYP) 1A2 in man and rabbit, yielding 5-hydroxythiabendazol...

In vitro and in silico identification and characterization of thiabendazole as a mechanism-based inhibitor of CYP1A2 and simulation of possible pharmacokinetic drug-drug interactions.

Drug Metab. Dispos. 37 , 1286-1294, (2009)

Thiabendazole (TBZ) and its major metabolite 5-hydroxythiabendazole (5OH-TBZ) were screened for potential time-dependent inhibition (TDI) against CYP1A2. Screen assays were carried out in the absence ...

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