CHYMASE

Names

[ Name ]:
CHYMASE

Biological Activity

[Description]:

Chymase is a protein-digester enzyme found primarily in mast cells (MC), fibroblasts, and vascular endothelial cells. Chymase is released into the extracellular stroma in the context of inflammatory signals, tissue injury and cellular stress. Chymase is also involved in angiotensin II (Ang II) production, which is used in cardiovascular disease studies[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Ahmad S, et al. Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010-2018). Expert Opin Ther Pat. 2018 Nov;28(11):755-764.

Chemical & Physical Properties

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
B

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

Articles

Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism.

Am. J. Physiol. Heart Circ. Physiol. 305(5) , H644-50, (2013)

Angiotensin-(1-12) [ANG-(1-12)], a new member of the renin-angiotensin system, is recognized as a renin independent precursor for ANG II. However, the processing of ANG-(1-12) in the circulation in vi...

Cathepsin C is a tissue-specific regulator of squamous carcinogenesis.

Genes Dev. 27(19) , 2086-98, (2013)

Serine and cysteine cathepsin (Cts) proteases are an important class of intracellular and pericellular enzymes mediating multiple aspects of tumor development. Emblematic of these is CtsB, reported to...

Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices.

Biochem. J. 458(2) , 291-9, (2014)

Heparanase cleaves macromolecular heparin in the secretory granules of connective tissue-type mast cells. We investigated roles of the cleavage under a microenvironment mimicking where the mast cells ...

Related Compounds

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