6-Bromooxindole

Names

[ Name ]:
6-Bromooxindole

[Synonym ]:
6-Bromo-1,3-dihydro-2H-indol-2-one
2H-Indol-2-one, 6-bromo-1,3-dihydro-
6-Bromooxindole
MFCD02179605

Biological Activity

[Description]:

6-Bromo-2-oxindole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

6-Bromo-2-oxindole 是一种从海鞘 (D. skoogi) 中分离出来的次级代谢产物。它对 MDA-MB-231 乳腺癌细胞具有细胞毒性，IC50 值为 74.41 μM。6-Bromo-2-oxindole 已用于合成 1,3-distributed 2-oxindoles 和 indolin-2-one p38α 抑制剂，它们具有抗炎活性。

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
343.6±42.0 °C at 760 mmHg

[ Melting Point ]:
217-221 °C(lit.)

[ Molecular Formula ]:
C₈H₆BrNO

[ Molecular Weight ]:
212.04

[ Flash Point ]:
161.6±27.9 °C

[ Exact Mass ]:
210.963272

[ PSA ]:
29.10000

[ LogP ]:
2.39

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.625

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles

Synthesis and biological evaluation of new pyridone-annelated isoindigos as anti-proliferative agents.

Molecules 19(9) , 13076-92, (2014)

A selected set of substituted pyridone-annelated isoindigos 3a-f has been synthesized via interaction of 5- and 6-substituted oxindoles 2a-f with 6-ethyl-1,2,9-trioxopyrrolo[3,2-f]quinoline-8-carboxyl...

Related Compounds

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