36687-76-0

36687-76-0 structure

Name: Isorhamnetin 3-glucuronide
Chemical Name: (2S,3S,4S,5R,6S)-6-[5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
CAS Number: 36687-76-0
Molecular Formula: C₂₂H₂₀O₁₃
Molecular Weight: 492.38600
Catalog: Research Areas Cancer
Create Date: 2016-11-27 13:23:34
Modify Date: 2024-01-03 17:00:52
Isorhamnetin 3-glucuronide is a potent anticancer agent. Isorhamnetin 3-glucuronide shows anti-proliferative activity. Isorhamnetin 3-glucuronide induces Apoptosis and cell cycle arrest at S-phase[1].

Name	(2S,3S,4S,5R,6S)-6-[5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Synonyms	Isorhamnetin 3-glucuronide

Description	Isorhamnetin 3-glucuronide is a potent anticancer agent. Isorhamnetin 3-glucuronide shows anti-proliferative activity. Isorhamnetin 3-glucuronide induces Apoptosis and cell cycle arrest at S-phase[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Isorhamnetin 3-glucuronide (0-100 µM; 48 h) 以剂量依赖的方式对 MCF-7 细胞显示出抗增殖活性[1]。 Isorhamnetin 3-glucuronide (0-100 µM; 48 h) 以剂量依赖性方式诱导细胞凋亡和细胞周期停滞在 S 期[1]。 Cell Proliferation Assay[1] Cell Line: MCF-7 cells Concentration: 0, 25, 50, 100 µM Incubation Time: 48 h Result: Inhibited cell proliferation in a dose-dependent manner. Apoptosis Analysis[1] Cell Line: MCF-7 cells Concentration: 25, 100 µM Incubation Time: 48 h Result: Induced apoptosis with the rate of 16.8%, 49.8% at 25, 100 µM, respectively. Cell Cycle Analysis[1] Cell Line: MCF-7 cells Concentration: 0, 50, 100 µM Incubation Time: 48 h Result: Induced cell cycle arrest at S-phase.
References	[1]. Wu Q, et al. Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells. J Agric Food Chem. 2018 Jul 11;66(27):7181-7189.