205187-53-7

205187-53-7 structure

Name: CX-157
Chemical Name: 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiine 10,10-dioxide
CAS Number: 205187-53-7
Molecular Formula: C₁₄H₈F₄O₄S
Molecular Weight: 348.27000
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2016-07-28 01:34:24
Modify Date: 2024-01-11 18:34:06
CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL.

Name	3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiine 10,10-dioxide
Synonyms	Phenoxathiin,3-fluoro-7-(2,2,2-trifluoroethoxy)-,10,10-dioxide CX157 CX-157

Description	CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	EC50: 19.3 ng/mL (MAO-A)[1]
In Vivo	CX-157 is a reversible inhibitor of monoamine oxidase-A (MAO-A) with an EC50 of 19.3 ng/mL. CX-157 is an investigational compound currently in development for the treatment of major depressive disorder (MDD). Mechanistic studies in animals have shown that CX-157 acts to inhibit MAO-A activity in a reversible and competitive manner, elevating brain levels of monoamine neurotransmitters[1].
References	[1]. Fowler JS, et al. Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology. 2010 Feb;35(3):623-31.