Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: polyketomycin
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200625-47-4

200625-47-4 structure

Name: polyketomycin
Chemical Name: polyketomycin
CAS Number: 200625-47-4
Molecular Formula: C₄₄H₄₈O₁₈
Molecular Weight: 864.84100
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-10-18 09:44:16
Modify Date: 2025-08-20 13:53:18
Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].

Name	polyketomycin

Description	Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Anti-infection >> Bacterial
Target	Traditional Cytotoxic Agents
In Vitro	Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC50 values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively[1].
In Vivo	The acute toxicity (LD50, ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg[1].
References	[1]. Momose I, et al. Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1998 Jan;51(1):21-5. [2]. Daum M, et al. Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem. 2009 Apr 17;10(6):1073-83. [3]. Otoguro K, In vitro antimalarial activities of the microbial metabolites. J Antibiot (Tokyo). 2003 Mar;56(3):322-4.

Molecular Formula	C₄₄H₄₈O₁₈
Molecular Weight	864.84100
Exact Mass	864.28400
PSA	279.18000
LogP	2.52400

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