142929-49-5

142929-49-5 structure

Name: Boc-O1Pen-OH * DCHA
Chemical Name: 2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]acetic acid
CAS Number: 142929-49-5
Molecular Formula: C₉H₁₇NO₅
Molecular Weight: 219.235
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-07 09:26:32
Modify Date: 2024-01-05 14:11:42
Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]acetic acid
Synonyms	Acetic acid, 2-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]- {2-[(tert-Butoxycarbonyl)amino]ethoxy}acetic acid [2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)ethoxy]acetic acid AmbotzBAA5240

Description	Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.2±0.1 g/cm3
Boiling Point	391.2±22.0 °C at 760 mmHg
Molecular Formula	C₉H₁₇NO₅
Molecular Weight	219.235
Flash Point	190.4±22.3 °C
Exact Mass	219.110672
PSA	84.86000
LogP	0.55
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.462

HS Code	2924199090

26690-80-2

79-11-8

~71%

142929-49-5

Literature: MYREXIS, INC.; BAJJI, Ashok, C.; TANGALLAPALLY, Rajendra, P.; KIM, In, Chul; KIM, Se, Ho; PARKER, Daniel, P.; TROVATO, Richard; PAPAC, Damon, I.; YAGER, Kraig; BAICHWAL, Vijay, R. Patent: WO2012/148550 A1, 2012 ; Location in patent: Page/Page column 50; 51 ;

142929-48-4

~71%

142929-49-5

Literature: Chandrakumar; Stapelfeld; Beardsley; Lopez; Drury; Anthony; Savage; Williamson; Reichman Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 2928 - 2938

142929-50-8

~75%

142929-49-5

Literature: Adamczyk, Maciej; Fishpaugh, Jeffrey R.; Thiruvazhi, Mohan Organic Preparations and Procedures International, 2002 , vol. 34, # 3 p. 326 - 331

24424-99-5

142929-49-5

Literature: Journal of Medicinal Chemistry, , vol. 35, # 16 p. 2928 - 2938

26690-80-2

142929-49-5

Literature: Organic Preparations and Procedures International, , vol. 34, # 3 p. 326 - 331

Precursor 3
26690-80-2 79-11-8 24424-99-5
DownStream 0

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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